A Case-Control Study on the Risk Factors for Meningococcal Disease among Children in Greece
| العنوان: | A Case-Control Study on the Risk Factors for Meningococcal Disease among Children in Greece |
|---|---|
| المؤلفون: | Georgia Tzanakaki, Vasiliki A. Vasilopoulou, Christos Hadjichristodoulou, George Rachiotis, Kalliopi Theodoridou, Maria Theodoridou, Vassiliki Syriopoulou, Antonios Katsioulis, George Mpalaouras |
| المصدر: | PLoS ONE PLoS ONE, Vol 11, Iss 6, p e0158524 (2016) |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, Bacterial Diseases, Pediatrics, Multivariate analysis, Pulmonology, lcsh:Medicine, Meningococcal Disease, Pathology and Laboratory Medicine, Habits, 0302 clinical medicine, Infectious Diseases of the Nervous System, Genotype, Smoking Habits, Medicine and Health Sciences, Public and Occupational Health, 030212 general & internal medicine, lcsh:Science, Child, Respiratory Tract Infections, Vaccines, Multidisciplinary, Respiratory tract infections, Greece, Vaccination and Immunization, Bacterial Pathogens, Infectious Diseases, Neurology, Research Design, Medical Microbiology, Child, Preschool, Female, Pathogens, Meningitis, Neisseria, Research Article, medicine.medical_specialty, Adolescent, Inflammatory Diseases, 030106 microbiology, Immunology, Meningococcal disease, Research and Analysis Methods, Mannose-Binding Lectin, Microbiology, 03 medical and health sciences, medicine, Humans, Microbial Pathogens, Behavior, Bacteria, business.industry, lcsh:R, Haplotype, Case-control study, Organisms, Infant, Biology and Life Sciences, Health Risk Analysis, medicine.disease, Meningococcal Infections, Health Care, Upper respiratory tract infection, Haplotypes, Case-Control Studies, Respiratory Infections, lcsh:Q, Tobacco Smoke Pollution, Preventive Medicine, business, Neisseria Meningitidis |
| الوصف: | Purpose The aim of this study was to identify environmental or genetic risk factors that are associated with invasive meningococcal disease (IMD) in children in Greece. Methods A case-control study was performed in 133 children (44 cases and 89 controls) aged between 0–14 years, who were hospitalized in a children's hospital in Athens. Demographics and possible risk factors were collected by the use of a structured questionnaire. To investigate the association of mannose binding lectin (MBL) with IMD, a frequency analysis of the haplotypes of the MBL2 gene and quantitative measurement of MBL serum protein levels were performed using Nanogen NanoChipR 400 technology and immuno-enzyme techniques, respectively. Results The multivariate analysis revealed that changes in a child's life setting (relocation or vacation, OR = 7.16), paternal smoking (OR = 4.51), upper respiratory tract infection within the previous month (OR = 3.04) and the density of people in the house/100m2 (OR = 3.16), were independent risk factors associated with IMD. Overall 18.8% of patients had a MBL2 genotype with low functionality compared to 10.1% of healthy controls, but this was not statistically significant (p = 0.189). Conclusion Prevention strategies aimed at reducing parental smoking and other risk factors identified in this study could decrease the risk of IMD among children in Greece. |
| تدمد: | 1932-6203 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d306e47a8549459f1133a5dd0858ef30 https://pubmed.ncbi.nlm.nih.gov/27351742 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d306e47a8549459f1133a5dd0858ef30 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
|---|