Bovine antibodies targeting primary and recurrent Clostridium difficile disease are a potent antibiotic alternative
| العنوان: | Bovine antibodies targeting primary and recurrent Clostridium difficile disease are a potent antibiotic alternative |
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| المؤلفون: | Bliss Cunningham, Dena Lyras, Julian I. Rood, Melanie L. Hutton, Kate E. Mackin, Meagan L. James, Shelley A. Lyon |
| المصدر: | Scientific Reports Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017) |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.drug_class, Science, medicine.medical_treatment, 030106 microbiology, Antibiotics, Cattle Diseases, Clostridium difficile toxin B, Cross Reactions, Article, Microbiology, 03 medical and health sciences, Mice, Antibiotic resistance, Bacterial Proteins, Antibody Specificity, Neutralization Tests, Recurrence, medicine, Animals, Hyperimmune Bovine Colostrum, Multidisciplinary, business.industry, Clostridioides difficile, Immunotherapy, Clostridium difficile, Antibiotic Prophylaxis, Antimicrobial, Antibodies, Bacterial, Antibodies, Neutralizing, Anti-Bacterial Agents, Repressor Proteins, Immunology, Clostridium Infections, Medicine, Colostrum, Cattle, business |
| الوصف: | The increased incidence of antibiotic resistant ‘superbugs’ has amplified the use of broad spectrum antibiotics worldwide. An unintended consequence of antimicrobial treatment is disruption of the gastrointestinal microbiota, resulting in susceptibility to opportunistic pathogens, such as Clostridium difficile. Paradoxically, treatment of C. difficile infections (CDI) also involves antibiotic use, leaving patients susceptible to re-infection. This serious health threat has led to an urgent call for the development of new therapeutics to reduce or replace the use of antibiotics to treat bacterial infections. To address this need, we have developed colostrum-derived antibodies for the prevention and treatment of CDI. Pregnant cows were immunised to generate hyperimmune bovine colostrum (HBC) containing antibodies that target essential C. difficile virulence components, specifically, spores, vegetative cells and toxin B (TcdB). Mouse infection and relapse models were used to compare the capacity of HBC to prevent or treat primary CDI as well as prevent recurrence. Administration of TcdB-specific colostrum alone, or in combination with spore or vegetative cell-targeted colostrum, prevents and treats C. difficile disease in mice and reduces disease recurrence by 67%. C. difficile-specific colostrum should be re-considered as an immunotherapeutic for the prevention or treatment of primary or recurrent CDI. |
| تدمد: | 2045-2322 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2cefe89c4606d88b8ed27bb5ba5e33b https://pubmed.ncbi.nlm.nih.gov/28623367 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d2cefe89c4606d88b8ed27bb5ba5e33b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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