Atmospheric pressure plasma jet-mouse skin interaction: Mitigation of damages by liquid interface and gas flow control
| العنوان: | Atmospheric pressure plasma jet-mouse skin interaction: Mitigation of damages by liquid interface and gas flow control |
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| المؤلفون: | Andrea Jurov, Špela Kos, Tanja Blagus, Ivana Sremački, Gregor Filipič, Nataša Hojnik, Anton Nikiforov, Christophe Leys, Maja Čemažar, Gregor Serša, Uroš Cvelbar |
| المصدر: | Biointerphases. 17:021004 |
| بيانات النشر: | American Vacuum Society, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Plasma Gases, integumentary system, General Physics and Astronomy, General Chemistry, Reactive Nitrogen Species, General Biochemistry, Genetics and Molecular Biology, Biomaterials, Mice, Atmospheric Pressure, atmospheric pressure plasma, plasma jet, cold plasma, Animals, General Materials Science, Gases, Reactive Oxygen Species |
| الوصف: | The possible benefits of an atmospheric pressure plasma jet skin treatment have been tested in vivo on mouse skin. Many studies have been conducted in vitro on mouse skin cells, but only a few in vivo where, due to the complexity of the biological system, plasma can cause severe damages. For this reason, we investigated how kHz plasma generated in a jet that is known to inflict skin damage interacts with mouse skin and explored how we can reduce the skin damage. First, the focus was on exploring plasma effects on skin damage formation with different plasma gases and jet inclinations. The results pointed to the perpendicular orientation of a He plasma jet as the most promising condition with the least skin damage. Then, the skin damage caused by a He plasma jet was explored, focusing on damage mitigation with different liquid interfaces applied to the treatment site, adding N2 to the gas mixture, or alternating the gas flow dynamics by elongating the jet's glass orifice with a funnel. All these mitigations proved highly efficient, but the utmost benefits for skin damage reduction were connected to skin temperature reduction, the reduction in reactive oxygen species (ROS), and the increase in reactive nitrogen species (RNS). |
| تدمد: | 1559-4106 1934-8630 |
| DOI: | 10.1116/6.0001596 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d22d2fda0765f622bc76b6adad8f07d0 https://doi.org/10.1116/6.0001596 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....d22d2fda0765f622bc76b6adad8f07d0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15594106 19348630 |
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| DOI: | 10.1116/6.0001596 |