T Cell Antigen Receptor Vaccines for Active Therapy of T Cell Malignancies
| العنوان: | T Cell Antigen Receptor Vaccines for Active Therapy of T Cell Malignancies |
|---|---|
| المؤلفون: | Sunil Reddy, Ronald Levya, Craig Okada, David W. Bahler, Carmen P. Wong |
| المصدر: | Annals of the New York Academy of Sciences. 941:97-105 |
| بيانات النشر: | Wiley, 2006. |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | Idiotype, Skin Neoplasms, T cell, medicine.medical_treatment, Genetic Vectors, Receptors, Antigen, T-Cell, Lymphoproliferative disorders, chemical and pharmacologic phenomena, Cancer Vaccines, Polymerase Chain Reaction, General Biochemistry, Genetics and Molecular Biology, Adenoviridae, Mice, Mycosis Fungoides, Immunoglobulin Idiotypes, History and Philosophy of Science, Antigen, Antigens, Neoplasm, Vaccines, DNA, medicine, Animals, Humans, Mycosis fungoides, Base Sequence, business.industry, General Neuroscience, T-cell receptor, Vaccine trial, Immunotherapy, medicine.disease, Lymphoproliferative Disorders, Survival Rate, medicine.anatomical_structure, Immunology, business |
| الوصف: | T cell lymphoproliferative disorders continue to be serious management problems, and so alternative therapeutic modalities are continuously being explored. One such strategy involves immunotherapy using the T cell receptor (TCR) as a target. Specifically we are attempting to develop a T cell receptor idiotype (TCR-Id) vaccine because the TCR-Id can serve as a tumor-specific antigen. In this article we will briefly review the rationale for TCR-Id vaccines, the preclinical models as developed in our laboratory, and a discussion of our current plans for a vaccine trial in mycosis fungoides. |
| تدمد: | 1749-6632 0077-8923 |
| DOI: | 10.1111/j.1749-6632.2001.tb03714.x |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d218974ed53091faa829812644072d83 https://doi.org/10.1111/j.1749-6632.2001.tb03714.x |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d218974ed53091faa829812644072d83 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17496632 00778923 |
|---|---|
| DOI: | 10.1111/j.1749-6632.2001.tb03714.x |