CYP450 and Its Implications in the Clinical Use of Antipsychotic Drugs
| العنوان: | CYP450 and Its Implications in the Clinical Use of Antipsychotic Drugs |
|---|---|
| المؤلفون: | C Álamo González, Juan de Dios Molina Martín, Francisco López-Muñoz, Fernando Mora, Elena Zubillaga |
| المصدر: | Depósito Digital e-UCJC Universidad Camilo José Cela (UCJC) |
| بيانات النشر: | Jun-Ping Liu, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Drug, food.ingredient, media_common.quotation_subject, medicine.medical_treatment, Coding (therapy), Pharmacokinetic, CYP450, Drug resistance, Pharmacology, Bioinformatics, Grapefruit juice, Drug interactions, 3201.05 Psicología Clínica, Antipsychotic, food, Pharmacokinetics, Medicine, Adverse effect, General Environmental Science, media_common, Polypharmacy, business.industry, Psicología, 3209 Farmacología, General Earth and Planetary Sciences, business |
| الوصف: | Polypharmacy implies a high potential for drug-drug interactions. The capacity of the cytochrome P450 enzyme system involved in the metabolism of psychoactive drugs differs greatly, which leads to variable drug elimination rates and inter-subject differences in serum drug concentrations. Polymorphisms in genes coding for CYP450 enzymes contribute to this inter-subject variability. Therapeutic response and adverse effects vary among patients treated with the same dose of a certain drug. Polypharmacy, comorbidity and the use of certain substances (grapefruit juice, caffeine and tobacco) increase the chances of clinically relevant interactions in a psychotic patient. Choosing drugs with low interaction potential seems to be the best strategy to prevent clinically relevant interactions particularly in elderly, polymedicated, oncologic and HIV patients. |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2114218976d52f0cd5e9d1c4e60d5d4 http://hdl.handle.net/20.500.12020/777 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d2114218976d52f0cd5e9d1c4e60d5d4 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |