The Crystal Structure of the MHC Class I (MHC-I) Molecule in the Green Anole Lizard Demonstrates the Unique MHC-I System in Reptiles
| العنوان: | The Crystal Structure of the MHC Class I (MHC-I) Molecule in the Green Anole Lizard Demonstrates the Unique MHC-I System in Reptiles |
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| المؤلفون: | Bing Zhang, Zehui Qu, Lizhen Ma, Yawen Wang, Xiaohui Wei, Nianzhi Zhang, Chun Xia |
| المصدر: | J Immunol |
| بيانات النشر: | The American Association of Immunologists, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Protein Conformation, Immunology, chemical and pharmacologic phenomena, Reptilian Proteins, Nidovirales, Nidovirales Infections, Crystallography, X-Ray, Major histocompatibility complex, Epitope, Evolution, Molecular, Epitopes, 03 medical and health sciences, 0302 clinical medicine, MHC class I, Animals, Immunology and Allergy, Amino Acid Sequence, Antigens, Viral, Peptide sequence, Gene, Phylogeny, MHC class II, Polymorphism, Genetic, biology, Protein Stability, Chemistry, C-terminus, Histocompatibility Antigens Class I, Mutagenesis, Immunity, Lizards, Evolutionary biology, Immune System, Molecular and Structural Immunology, biology.protein, 030215 immunology |
| الوصف: | The reptile MHC class I (MCH-I) and MHC class II proteins are the key molecules in the immune system; however, their structure has not been investigated. The crystal structure of green anole lizard peptide–MHC-I–β2m (pMHC-I or pAnca-UA*0101) was determined in the current study. Subsequently, the features of pAnca-UA*0101 were analyzed and compared with the characteristics of pMHC-I of four classes of vertebrates. The amino acid sequence identities between Anca-UA*0101 and MHC-I from other species are |
| تدمد: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.2000992 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1dca751e77b885d142285c56592de9c https://doi.org/10.4049/jimmunol.2000992 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d1dca751e77b885d142285c56592de9c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15506606 00221767 |
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| DOI: | 10.4049/jimmunol.2000992 |