Mesoscopic Modeling of the Encapsulation of Capsaicin by Lecithin/Chitosan Liposomal Nanoparticles
| العنوان: | Mesoscopic Modeling of the Encapsulation of Capsaicin by Lecithin/Chitosan Liposomal Nanoparticles |
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| المؤلفون: | Armando Gama Goicochea, Evelin Martínez-Benavidez, Roberto López-Rendón, Inocencio Higuera-Ciapara, Waldo Argüelles-Monal, Francisco M. Goycoolea, Javier Hernández, Claudia Virués, Ketzasmin A. Terrón-Mejía, Zaira Domínguez |
| المصدر: | Nanomaterials, Vol 8, Iss 6, p 425 (2018) Nanomaterials Volume 8 Issue 6 |
| بيانات النشر: | MDPI AG, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Biodistribution, food.ingredient, General Chemical Engineering, Nanoparticle, 02 engineering and technology, macromolecular substances, 010402 general chemistry, 01 natural sciences, Lecithin, capsaicin, Article, Nanocapsules, dissipative particle dynamics, Chitosan, lcsh:Chemistry, chemistry.chemical_compound, food, General Materials Science, Solubility, Liposome, Chemistry, technology, industry, and agriculture, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Hydrophobe, lecithin, Chemical engineering, lcsh:QD1-999, lipids (amino acids, peptides, and proteins), chitosan, 0210 nano-technology |
| الوصف: | The transport of hydrophobic drugs in the human body exhibits complications due to the low solubility of these compounds. With the purpose of enhancing the bioavailability and biodistribution of such drugs, recent studies have reported the use of amphiphilic molecules, such as phospholipids, for the synthesis of nanoparticles or nanocapsules. Given that phospholipids can self-assemble in liposomes or micellar structures, they are ideal candidates to function as vehicles of hydrophobic molecules. In this work, we report mesoscopic simulations of nanoliposomes, constituted by lecithin and coated with a shell of chitosan. The stability of such structures and the efficiency of the encapsulation of capsaicin, as well as the internal and superficial distribution of capsaicin and chitosan inside the nanoliposome, were analyzed. The characterization of the system was carried out through density maps and the potentials of mean force for the lecithin-capsaicin, lecithin-chitosan, and capsaicin-chitosan interactions. The results of these simulations show that chitosan is deposited on the surface of the nanoliposome, as has been reported in some experimental works. It was also observed that a nanoliposome of approximately 18 nm in diameter is stable during the simulation. The deposition behavior was found to be influenced by a pattern of N-acetylation of chitosan. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2079-4991 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1aa7f84a8bc016ccdc42709bd383329 http://www.mdpi.com/2079-4991/8/6/425 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d1aa7f84a8bc016ccdc42709bd383329 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20794991 |
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