Infection-related hospitalization after intensive immunosuppressive therapy among lupus nephritis and ANCA glomerulonephritis patients
| العنوان: | Infection-related hospitalization after intensive immunosuppressive therapy among lupus nephritis and ANCA glomerulonephritis patients |
|---|---|
| المؤلفون: | Qiong Wen, Qing Ye, Xueqing Yu, Jianbo Li, Zhong Zhong, Junxian Wang, Peihong Yin, Jing Yu, Fengxian Huang, Wenyi Liang, Xiao Yang, Yagui Qiu |
| المصدر: | Renal Failure, Vol 42, Iss 1, Pp 474-482 (2020) Renal Failure |
| بيانات النشر: | Taylor & Francis Group, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Time Factors, anca glomerulonephritis, medicine.medical_treatment, 030232 urology & nephrology, Lupus nephritis, 030204 cardiovascular system & hematology, Critical Care and Intensive Care Medicine, Infections, lcsh:RC870-923, Antibodies, Antineutrophil Cytoplasmic, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Glomerulonephritis, immune system diseases, Risk Factors, Internal medicine, medicine, Humans, In patient, skin and connective tissue diseases, Proportional Hazards Models, Retrospective Studies, lupus nephritis, immunosuppression, business.industry, Immunosuppression, General Medicine, Middle Aged, medicine.disease, lcsh:Diseases of the genitourinary system. Urology, infection, Survival Rate, Nephrology, Multivariate Analysis, Clinical Study, Female, business, Immunosuppressive Agents, Glomerular Filtration Rate, hospitalization |
| الوصف: | Introduction: This study aimed to investigate the clinical characteristics, risk factors, and outcomes of infection-related hospitalization (IRH) in patients with lupus nephritis (LN) and ANCA glomerulonephritis after intensive immunosuppressive therapy. Methods: Patients diagnosed with LN or ANCA glomerulonephritis who received intensive immunosuppressive therapy at the First Affiliated Hospital of Sun Yat-sen University from 2005 to 2014 were enrolled. Demographics, laboratory parameters, immunosuppressive agents, and IRH details were collected. Multivariable Cox regression was used, and hazard ratios (HRs) and 95% confidence intervals (CIs) were reported. Results: Totally, 872 patients with 806 LN and 66 ANCA glomerulonephritis were enrolled, and 304 (34.9%) patients with 433 episodes of IRH were recorded. ANCA glomerulonephritis patients were more vulnerable to IRH than LN patients (53.0% vs. 33.4%, p = .001). Multivariable Cox regression analysis showed that ANCA glomerulonephritis (HR = 1.62, 95% CI: 1.06–2.49, p = .027), diabetes (HR = 1.82, 95% CI: 1.03–3.22, p = .039) and a higher initial dose of prednisone (HR = 1.01, 95% CI: 1.00–1.02, p = .013) were associated with a higher likelihood of IRH. Higher albumin (HR = 0.96, 95% CI: 0.94–0.98, p |
| اللغة: | English |
| تدمد: | 1525-6049 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d15c98b7a145c3773851fca1e1fdb94d https://doaj.org/article/ded72ccdb45549f6a9db39ee8cff7bf1 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d15c98b7a145c3773851fca1e1fdb94d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15256049 |
|---|