The Role of Urinary Neutrophil Gelatinase-Associated Lipocalin in Predicting Acute Kidney Dysfunction in Patients With Liver Cirrhosis
| العنوان: | The Role of Urinary Neutrophil Gelatinase-Associated Lipocalin in Predicting Acute Kidney Dysfunction in Patients With Liver Cirrhosis |
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| المؤلفون: | Abdulla Al Sayyari, Waleed Tamimi, Abdulrahman Aljumah, Salem Al Qurashi, Mohamed A Saeed, Hani Tamim, Hanan Alfawaz, Abdulaziz Al Dawood |
| المصدر: | Journal of Clinical Medicine Research |
| بيانات النشر: | Elmer Press, Inc., 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Renal failure, medicine.medical_specialty, Cirrhosis, Urinary system, Renal function, Lipocalin, behavioral disciplines and activities, Gastroenterology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Internal medicine, medicine, Acute kidney dysfunction, In patient, Creatinine, business.industry, Area under the curve, General Medicine, Odds ratio, medicine.disease, MELD, uNGAL, chemistry, 030220 oncology & carcinogenesis, Liver cirrhosis, Original Article, 030211 gastroenterology & hepatology, business |
| الوصف: | Background: Early detection of acute kidney dysfunction (AKD) in cirrhotic patients is crucial. Urinary neutrophil gelatinase-associated lipocalin (uNGAL) has been identified as an early marker of AKD. The aim of the study was to evaluate serial uNGAL as a marker and predictor of AKD in liver cirrhosis patients. Methods: Serial uNGAL and serum creatinine (sCr) levels were measured daily during the first 6 days of admission. Furthermore, sCr levels and the estimated glomerular filtration rate (eGFR) were measured after 3 - 6 weeks. The uNGAL levels in patients with and without abnormal sCr were compared. Results: Fifty-seven consecutive cirrhotic patients were enrolled in the study. Eight of 14 patients (57%) who developed abnormal uNGAL level also had abnormal sCr level (odds ratio (OR) = 3.4, 95% CI: 0.99 - 12.03, P = 0.05). After 6 weeks, 41% of patients exhibited an abnormal uNGAL level and abnormal sCr (OR = 6.7, 95% CI: 1.55 - 28.85, P = 0.01). Area under the curve (AUROC) and the best cut-off point for highest NGAL in 6 days were 0.64 and 72.55 ng/mL, respectively. Conclusions: There is a modest association between highest uNGAL in the first 6 days of admission and sCr at week 6 in all participants. This may indicate that in cirrhotic patients, uNGAL level during the first 6 days of admission has a potential predictability for the development of high sCr and low eGFR 6 weeks later. The AUROC of 0.64 quantifies the overall ability of uNGAL to discriminate between those individuals who will have a raised sCr levels and those who will not. J Clin Med Res. 2018;10(5):419-428 doi: https://doi.org/10.14740/jocmr3366w |
| تدمد: | 1918-3011 1918-3003 |
| DOI: | 10.14740/jocmr3366w |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d10d364930825a394be800039feb0aea https://doi.org/10.14740/jocmr3366w |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d10d364930825a394be800039feb0aea |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19183011 19183003 |
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| DOI: | 10.14740/jocmr3366w |