التفاصيل البيبلوغرافية
| العنوان: |
Message in a bottle: lessons learned from antagonism of STING signalling during RNA virus infection |
| المؤلفون: |
Maringer, Kevin, Fernandez-Sesma, Ana |
| المصدر: |
Cytokine & Growth Factor Reviews |
| بيانات النشر: |
The Authors. Published by Elsevier Ltd. |
| مصطلحات موضوعية: |
cGAMP, cyclic GMP-AMP, Endocrinology, Diabetes and Metabolism, BiFC, bimolecular fluorescence complementation, viruses, PI(3)K, phosphatidylinositol-3-OH kinase, RIG-I, retinoic acid-inducible gene I, Dengue virus, medicine.disease_cause, Severe Acute Respiratory Syndrome, Dengue, Mice, DC, dendritic cell, Coronaviridae, Immunology and Allergy, MDA-5, melanoma differentiation-associated gene 5, 0303 health sciences, PLpro, papain-like protease, biology, RIG-I, Immune evasion, Hepatitis C virus, 030302 biochemistry & molecular biology, DUB, deubiquitinase, Nucleotidyltransferases, 3. Good health, Flavivirus, PBMC, peripheral blood mononuclear cells, Severe acute respiratory syndrome-related coronavirus, CARD, caspase activation and recruitment domain, Stimulator of interferon genes, ISRE, interferon-stimulated response element, Signal Transduction, SARS coronavirus, Mini Review, Immunology, STING, stimulator of interferon genes, General Biochemistry, Genetics and Molecular Biology, TRIM32, tripartite motif-containing 32, PLP, papain-like protease, 03 medical and health sciences, Viral Proteins, medicine, ISG, interferon-stimulated gene, TBK1, tank-binding kinase 1, Animals, Humans, IFN, interferon, IRF-3, interferon regulatory factor 3, STAT2, signal transducer and activator of transcription 2, mSTING, murine STING, 030304 developmental biology, Cyclic GMP-AMP synthase, Biochemistry, Genetics and Molecular Biology(all), Membrane Proteins, RNA virus, MAVS, mitochondrial antiviral signalling protein, Dengue Virus, biology.organism_classification, Virology, eye diseases, TRIM56, tripartite motif-containing 56, Sting, Coronavirus NL63, Human, cGAS, cyclic GMP-AMP synthase, hSTING, human STING, MAM, mitochondria-associated membrane, mKG, monomeric Kusabira Green, MDDC, monocyte-derived dendritic cell, STING |
| الوصف: |
STING has emerged in recent years as an important signalling adaptor in the activation of type I interferon responses during infection with DNA viruses and bacteria. An increasing body of evidence suggests that STING also modulates responses to RNA viruses, though the mechanisms remain less clear. In this review, we give a brief overview of the ways in which STING facilitates sensing of RNA viruses. These include modulation of RIG-I-dependent responses through STING's interaction with MAVS, and more speculative mechanisms involving the DNA sensor cGAS and sensing of membrane remodelling events. We then provide an in-depth literature review to summarise the known mechanisms by which RNA viruses of the families Flaviviridae and Coronaviridae evade sensing through STING. Our own work has shown that the NS2B/3 protease complex of the flavivirus dengue virus binds and cleaves STING, and that an inability to degrade murine STING may contribute to host restriction in this virus. We contrast this to the mechanism employed by the distantly related hepacivirus hepatitis C virus, in which STING is bound and inactivated by the NS4B protein. Finally, we discuss STING antagonism in the coronaviruses SARS coronavirus and human coronavirus NL63, which disrupt K63-linked polyubiquitination and dimerisation of STING (both of which are required for STING-mediated activation of IRF-3) via their papain-like proteases. We draw parallels with less-well characterised mechanisms of STING antagonism in related viruses, and place our current knowledge in the context of species tropism restrictions that potentially affect the emergence of new human pathogens. |
| وصف الملف: |
text |
| اللغة: |
English |
| تدمد: |
1359-6101 |
| DOI: |
10.1016/j.cytogfr.2014.08.004 |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d10cc600cce885a52a025195498f660d |
| Rights: |
OPEN |
| رقم الانضمام: |
edsair.doi.dedup.....d10cc600cce885a52a025195498f660d |
| قاعدة البيانات: |
OpenAIRE |