The plasma lipidome in acute myeloid leukemia at diagnosis in relation to clinical disease features
| العنوان: | The plasma lipidome in acute myeloid leukemia at diagnosis in relation to clinical disease features |
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| المؤلفون: | Jeffrey R. Idle, Diren Beyoğlu, Georg Martin Fiedler, Thomas Pabst, Uta Ceglarek, Linda Kortz |
| المصدر: | Pabst, Thomas; Kortz, Linda; Fiedler, Georg Martin; Ceglarek, Uta; Idle, Jeffrey; Beyoglu, Diren (2017). The plasma lipidome in acute myeloid leukemia at diagnosis in relation to clinical disease features. BBA clinical, 7, pp. 105-114. Elsevier 10.1016/j.bbacli.2017.03.002 <http://dx.doi.org/10.1016/j.bbacli.2017.03.002> BBA Clinical |
| بيانات النشر: | Elsevier BV, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, FAA, fatty acid amide, AA, arachidonic acid, TG, triacylglycerol (triglyceride), chemistry.chemical_compound, PC, phosphatidylcholine, PGF1α, prostaglandin 1α, 0302 clinical medicine, PCA, principal components analysis, Blast cell number, UPLC-ESI-QTOFMS, ultraperformance liquid chromatography-electrospray ionization-quadrupole time-of-flight mass spectrometry, hemic and lymphatic diseases, MUFA, monounsaturated fatty acid, DG, diacylglycerol, Prognostic risk, CML, chronic myelogenous leukemia, DIC, disseminated intravascular coagulation, 12-HEPE, 12-hydroxy-5Z,8Z,10E,14Z,17Z-eicosapentaenoic acid, 610 Medicine & health, AML, acute myeloid leukemia, chemistry.chemical_classification, GCMS, gas chromatography–mass spectrometry, Myeloid leukemia, EPA, eicosapentaenoic acid (20:5, 5Z,8Z,11Z,14Z,17Z), Regular Article, SCD1, stearoyl CoA desaturase 1, PLS-DA, projection to latent structures-discriminant analysis, Lipidome, FLC-QqLIT-MS, fast liquid chromatography-quadrupole linear ion-trap mass spectrometry, MRM, multiple reactions monitoring, Biochemistry, 030220 oncology & carcinogenesis, Molecular Medicine, Arachidonic acid, lipids (amino acids, peptides, and proteins), POEA, palmitoleoyl ethanolamide, Polyunsaturated fatty acid, ESI +, electrospray ionization positive mode, LPE, lysophosphatidylethanolamine, 2HG, (R)-2-hydroxyglutarate, PGH2, prostaglandin H2, MG, monoacylglycerol, Cer, ceramide, PE, phosphatidylethanolamine, CE, cholesterol ester, Pathology and Forensic Medicine, 03 medical and health sciences, PGF2α, prostaglandin F2α, Physiology (medical), 2OG, 2-oxoglutarate, Lipidomics, PUFA, polyunsaturated fatty acid, PGE2, prostaglandin E2, Fatty acids, TxB2, thromboxane B2, mPGES-1, microsomal prostaglandin E synthase-1, LPC, lysophosphatidylcholine, SM, sphingomyelin, Acute myeloid leukemia, Cholesterol, 12-LOX, 12-lipoxygenase, FAME, fatty acid methyl ester, Fatty acid, TxA2, thromboxane A2, OPLS-DA, orthogonal PLS-DA, CPT1a, carnitine palmitate transferase 1a, ALL, acute lymphoblastic leukemia, Sphingolipid, CoQ10, coenzyme Q10, ESI-, electrospray ionization negative mode, 8,9-DHET, 8,9-dihydroxy-5Z,11Z,14Z-eicosatrienoic acid, 030104 developmental biology, chemistry, FAB, French-American-British classification, DGLA, dihomo-γ-linoleic acid, Cancer research, Eicosanoids, FAO, fatty acid oxidation |
| الوصف: | Background Early studies established that certain lipids were lower in acute myeloid leukemia (AML) cells than normal leukocytes. Because lipids are now known to play an important role in cell signaling and regulation of homeostasis, and are often perturbed in malignancies, we undertook a comprehensive lipidomic survey of plasma from AML patients at time of diagnosis and also healthy blood donors. Methods Plasma lipid profiles were measured using three mass spectrometry platforms in 20 AML patients and 20 healthy blood donors. Data were collected on total cholesterol and fatty acids, fatty acid amides, glycerolipids, phospholipids, sphingolipids, cholesterol esters, coenzyme Q10 and eicosanoids. Results We observed a depletion of plasma total fatty acids and cholesterol, but an increase in certain free fatty acids with the observed decline in sphingolipids, phosphocholines, triglycerides and cholesterol esters probably driven by enhanced fatty acid oxidation in AML cells. Arachidonic acid and precursors were elevated in AML, particularly in patients with high bone marrow (BM) or peripheral blasts and unfavorable prognostic risk. PGF2α was also elevated, in patients with low BM or peripheral blasts and with a favorable prognostic risk. A broad panoply of lipid classes is altered in AML plasma, pointing to disturbances of several lipid metabolic interconversions, in particular in relation to blast cell counts and prognostic risk. Conclusions These data indicate potential roles played by lipids in AML heterogeneity and disease outcome. General significance Enhanced catabolism of several lipid classes increases prognostic risk while plasma PGF2α may be a marker for reduced prognostic risk in AML. Graphical abstract The AML lipidomic landscape.Image 2 Highlights • Many lipids are depleted in AML plasma likely due to induced fatty acid oxidation • Plasma arachidonic acid and precursors correlated with unfavorable prognostic risk • Plasma PGF2α at diagnosis correlated with favorable prognostic risk • Many metabolic interconversions perturbed in relation to blast cell numbers • AML heterogeneity related to plasma lipidome disturbances |
| وصف الملف: | application/pdf |
| تدمد: | 2214-6474 |
| DOI: | 10.1016/j.bbacli.2017.03.002 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0d3410160f8bd28df0354d9fef3e46d |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d0d3410160f8bd28df0354d9fef3e46d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22146474 |
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| DOI: | 10.1016/j.bbacli.2017.03.002 |