Mechanical Influence of Surrounding Soft Tissue on Bone Regeneration Processes: A Bone Lengthening Study
| العنوان: | Mechanical Influence of Surrounding Soft Tissue on Bone Regeneration Processes: A Bone Lengthening Study |
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| المؤلفون: | Jaime Domínguez, Rocío Navarrete-Calvo, Pablo Blázquez-Carmona, Juan Mora-Macías, Esther Reina-Romo, J.A. Sanz-Herrera, Juan Morgaz |
| المساهمون: | Junta de Andalucía, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España) |
| المصدر: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Distraction osteogenesis, Bone Regeneration, medicine.medical_treatment, 0206 medical engineering, education, Biomedical Engineering, Osteogenesis, Distraction, Viscoelastic model, 02 engineering and technology, Bone healing, Bone callus, behavioral disciplines and activities, Surrounding soft tissue, Models, Biological, Bone Lengthening, Mechanobiology, Distraction, In vivo, medicine, Animals, Bone transport, Bone regeneration, Metatarsal Bones, Sheep, business.industry, Distraction forces, Soft tissue, 020601 biomedical engineering, humanities, Biomechanical Phenomena, Tissue relaxation, Female, business, psychological phenomena and processes, Biomedical engineering |
| الوصف: | Bone lengthening is a bone regeneration technique with multiple clinical applications. One of the most common complications of this treatment is the lack of adaptation of the surrounding soft tissue to their extension. A better understanding of the mechanobiology of the tissues involved in distraction osteogenesis would allow better control of the clinical cases. Bone lengthening treatments were performed in vivo in the metatarsus of Merino sheep, measuring the distraction forces by means of an instrumented fixator. The tissue relaxation after distraction was analyzed in this study. A viscoelastic model was also applied to distraction data to assess the mechanical behavior of the tissues during the distraction phase. Tissue relaxation is similar to other bone regeneration processes which do not imply surrounding soft tissue extension, e.g. bone transport. The effects of this tissue on distraction forces are limited to the first minutes of distraction and elongations above 4% of the original length with the protocol applied. Moreover, the surrounding soft tissue initially loses some of its viscoelasticity and subsequently suffers strain hardening from day 5 of distraction until the end of the distraction phase, day 15. Finally, anatomical changes were also evidenced in the elongated limb of our specimens. We thank the Junta de Andalucía and the Ministerio de Economía y Competitividad from the Government of Spain for funding this research (US1261691, DPI2017-82501-P and PGC2018-097257-BC31), and the FPU Grant of one of the authors (FPU17/05361). |
| تدمد: | 1573-9686 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0cad52d93e089cead7dd82d25d09158 https://pubmed.ncbi.nlm.nih.gov/32808118 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d0cad52d93e089cead7dd82d25d09158 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15739686 |
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