Activating Nrf2 signalling alleviates osteoarthritis development by inhibiting inflammasome activation
| العنوان: | Activating Nrf2 signalling alleviates osteoarthritis development by inhibiting inflammasome activation |
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| المؤلفون: | Weihui Qi, Zeng Lin, Jingdi Zhan, Xinghe Xue, Yulong Zhou, Zijian Yan, Xiaoyun Pan, Jian Lin |
| المصدر: | Journal of Cellular and Molecular Medicine |
| بيانات النشر: | John Wiley and Sons Inc., 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Cartilage, Articular, Lipopolysaccharides, Male, Small interfering RNA, Licochalcone A, Inflammasomes, NF-E2-Related Factor 2, Interleukin-1beta, Arthritis, Inflammation, Apoptosis, Chondrocyte, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, Chalcones, Chondrocytes, NLR Family, Pyrin Domain-Containing 3 Protein, Osteoarthritis, medicine, Pyroptosis, Animals, RNA, Small Interfering, Aggrecan, Plant Extracts, Interleukin-18, Inflammasome, Cell Biology, Original Articles, medicine.disease, NLRP3 inflammasome, Cell biology, Mice, Inbred C57BL, 030104 developmental biology, medicine.anatomical_structure, chemistry, 030220 oncology & carcinogenesis, chondrocyte, Molecular Medicine, Original Article, medicine.symptom, medicine.drug, Signal Transduction |
| الوصف: | Osteoarthritis (OA), which is characterized by proliferation of subchondral bone and the degeneration of articular cartilage, is the most prevalent human arthritis. Nod‐like receptor pyrin domain 3 (NLRP3) inflammasome is a hot spot in recent year and has been reported to be associated with OA synovial inflammation. However, there are few studies on NLRP3 inflammasome in chondrocyte. Licochalcone A (Lico A), a compound extracted from Glycyrrhiza species, has various biological effects such as anti‐inflammation, anti‐apoptotic, anti‐cancer and anti‐oxidation. In this study, we investigated the protective effect of Lico A on chondrocytes stimulated by lipopolysaccharide (LPS) and surgically induced OA models. In vitro, Lico A could reduce the expression of NLRP3, apoptosis‐associated speck‐like protein (ASC), Gasdermin D (GSDMD), caspase‐1, interleukin‐1beta (IL‐1β) and IL‐18, which indicated that Lico A attenuates LPS‐induced chondrocytes pyroptosis. In addition, Lico A ameliorates the degradation of extracellular matrix (ECM) by enhancing the expression of aggrecan and collagen‐II. Meanwhile, we found that Lico A inhibits NLRP3 inflammasome via nuclear factor erythroid‐2‐related factor 2 (Nrf2)/haeme oxygenase‐1(HO‐1)/nuclear factor kappa‐B (NF‐κB) axis. And the Nrf2 small interfering RNA (siRNA) could reverse the anti‐pyroptosis effects of Lico A in mouse OA chondrocytes. In vivo, Lico A mitigates progression OA in a mouse model and reduces OA Research Society International (OARSI) scores. Thus, Lico A may have therapeutic potential in OA. |
| اللغة: | English |
| تدمد: | 1582-4934 1582-1838 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0ba57a1e1dbe85db1db3dcf49d36727 http://europepmc.org/articles/PMC7701566 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d0ba57a1e1dbe85db1db3dcf49d36727 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15824934 15821838 |
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