Fibrinolytic Capacity of Desmoteplase Compared to Tissue Plasminogen Activator in Rabbit Eyes
| العنوان: | Fibrinolytic Capacity of Desmoteplase Compared to Tissue Plasminogen Activator in Rabbit Eyes |
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| المؤلفون: | Simon A. Pot, Katrin Voelter, Christoph Tappeiner, Fernando Laguna Sanz, Deborah Bruetsch, Karina Klein, Nicole Borel |
| المساهمون: | University of Zurich, Voelter, Katrin |
| المصدر: | Journal of Ocular Pharmacology and Therapeutics. 35:66-75 |
| بيانات النشر: | Mary Ann Liebert Inc, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Administration, Topical, 10184 Institute of Veterinary Pathology, Pharmacology, Eye, Tissue plasminogen activator, Fibrin, Plasminogen Activators, 03 medical and health sciences, 0302 clinical medicine, Fibrinolytic Agents, In vivo, medicine, 2736 Pharmacology (medical), Animals, Desmoteplase, Pharmacology (medical), 610 Medicine & health, 630 Agriculture, Dose-Response Relationship, Drug, biology, business.industry, Rabbit (nuclear engineering), 2731 Ophthalmology, medicine.disease, 10226 Department of Molecular Mechanisms of Disease, Ophthalmology, 3004 Pharmacology, 030104 developmental biology, Tissue Plasminogen Activator, Toxicity, 030221 ophthalmology & optometry, biology.protein, 570 Life sciences, Female, 10090 Equine Department, Rabbits, Injections, Intraocular, Ophthalmic Solutions, business, Uveitis, medicine.drug |
| الوصف: | PURPOSE Desmoteplase (DSPA) was evaluated and compared with tissue plasminogen activator (t-PA) for its intraocular fibrinolytic effect and short-term toxicity in an in vivo study using rabbit eyes. METHODS Fibrin clots were induced in the anterior chamber of 44 rabbit eyes, and drug efficacy was measured by clot size reduction over 24 h. Topical DSPA eye drops (1.4 and 2 mg/mL) were compared with vehicle solution in a multiple-drop regimen in 8 animals per group. Intracameral injections of 0.6 μg DSPA (n = 14) and 25 μg t-PA (n = 14) were evaluated for their fibrinolytic efficacy. Animals were euthanized 24 h after drug application. RESULTS No significant differences were seen between topically treated DSPA and vehicle-treated animals. Intracameral t-PA had a higher fibrinolytic efficacy than DSPA at early time points, but no significant difference was seen between both groups at 24-h postapplication. Animals with t-PA treatment demonstrated significantly more side effects compared with DSPA-treated animals. DSPA showed no-to-mild side effects after topical and intracameral treatment. Histologically, no toxic effects were observed in any globe. CONCLUSIONS DSPA is a promising drug with fewer side effects and similar fibrinolytic efficacy compared with t-PA 24 h after intracameral application in rabbit eyes at the tested concentration. Drug efficacy might be improved by increasing intracameral DSPA doses. |
| وصف الملف: | jop.2018.0070.pdf - application/pdf |
| تدمد: | 1557-7732 1080-7683 |
| DOI: | 10.1089/jop.2018.0070 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0a86aac7704a39ba42bbd97657adfd6 https://doi.org/10.1089/jop.2018.0070 |
| Rights: | RESTRICTED |
| رقم الانضمام: | edsair.doi.dedup.....d0a86aac7704a39ba42bbd97657adfd6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15577732 10807683 |
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| DOI: | 10.1089/jop.2018.0070 |