Association of 152 Biomarker Reference Intervals with All-Cause Mortality in Participants of a General United States Survey from 1999 to 2010
| العنوان: | Association of 152 Biomarker Reference Intervals with All-Cause Mortality in Participants of a General United States Survey from 1999 to 2010 |
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| المؤلفون: | John P. A. Ioannidis, Chirag J. Patel, Glenn M. Chertow, Nam Pho, John T. Leppert, Arjun K. Manrai |
| المصدر: | Clinical chemistry |
| بيانات النشر: | Oxford University Press (OUP), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, Percentile, National Health and Nutrition Examination Survey, Clinical Biochemistry, Population, MEDLINE, 030204 cardiovascular system & hematology, Article, 03 medical and health sciences, 0302 clinical medicine, Reference Values, Cause of Death, Humans, Medicine, 030212 general & internal medicine, education, Aged, education.field_of_study, business.industry, Biochemistry (medical), Red blood cell distribution width, Middle Aged, Nutrition Surveys, United States, Cohort, Biomarker (medicine), Female, Observational study, business, Biomarkers, Demography |
| الوصف: | Background Physicians sometimes consider whether or not to perform diagnostic testing in healthy people, but it is unknown whether nonextreme values of diagnostic tests typically encountered in such populations have any predictive ability, in particular for risk of death. The goal of this study was to quantify the associations among population reference intervals of 152 common biomarkers with all-cause mortality in a representative, nondiseased sample of adults in the United States. Methods The study used an observational cohort derived from the National Health and Nutrition Examination Survey (NHANES), a representative sample of the United States population consisting of 6 survey waves from 1999 to 2010 with linked mortality data (unweighted N = 30 651) and a median followup of 6.1 years. We deployed an X-wide association study (XWAS) approach to systematically perform association testing of 152 diagnostic tests with all-cause mortality. Results After controlling for multiple hypotheses, we found that the values within reference intervals (10–90th percentiles) of 20 common biomarkers used as diagnostic tests or clinical measures were associated with all-cause mortality, including serum albumin, red cell distribution width, serum alkaline phosphatase, and others after adjusting for age (linear and quadratic terms), sex, race, income, chronic illness, and prior-year healthcare utilization. All biomarkers combined, however, explained only an additional 0.8% of the variance of mortality risk. We found modest year-to-year changes, or changes in association from survey wave to survey wave from 1999 to 2010 in the association sizes of biomarkers. Conclusions Reference and nonoutlying variation in common biomarkers are consistently associated with mortality risk in the US population, but their additive contribution in explaining mortality risk is minor. |
| تدمد: | 1530-8561 0009-9147 |
| DOI: | 10.1093/clinchem/hvaa271 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d030e5b5064a7f4d3c53b66d053d0d9c https://doi.org/10.1093/clinchem/hvaa271 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d030e5b5064a7f4d3c53b66d053d0d9c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15308561 00099147 |
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| DOI: | 10.1093/clinchem/hvaa271 |