Emerging viruses: why they are not jacks of all trades?
| العنوان: | Emerging viruses: why they are not jacks of all trades? |
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| المؤلفون: | Santiago F. Elena, Julia Hillung, Stéphanie Bedhomme |
| المساهمون: | Ministerio de Economía, Industria y Competitividad (España) |
| المصدر: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| بيانات النشر: | Elsevier BV, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Fitness landscape, Genetic Fitness, Biology, Virus Physiological Phenomena, Communicable Diseases, Emerging, Virology, Genetic Pleiotropy, Animals, Humans, Pandemics, Emerging viruses, Genetics, Models, Genetic, Host (biology), Genetic Variation, Epistasis, Genetic, Plants, Adaptation, Physiological, Biological Evolution, Pleiotropy (drugs), Virus Diseases, Evolutionary biology, Mutation, Viruses, Epistasis, Adaptation |
| الوصف: | 3 gráficas In order to limit the impact of the recent pandemics ignited by viral host jumps, it is necessary to better understand the ecological and evolutionary factors influencing the early steps of emergence and the interactions between them. Antagonistic pleiotropy, i.e. the negative fitness effect in the primary host of mutations allowing the infection of and the multiplication in a new host, has long been thought to be the main limitation to the evolution of generalist viruses and thus to emergence. However, the accumulation of experimental examples contradicting the hypothesis of antagonistic pleiotropy has highlighted the importance of other factors such as the epistasis between mutations increasing the adaptation to a new host. Epistasis is pervasive in viruses, affects the shape of the adaptive landscape and consequently the accessibility of evolutionary pathways. Finally, recent studies have gone steps further in the complexity of viral fitness determinism and stressed the potential importance of the epistatic pleiotropy and of the impact of host living conditions. We thank our lab mates for exciting discussions on the topic of this review. This work was supported by the Spanish Secretaría de Estado de Investigación,Desarrollo e Innovación grant BFU2012-30805. |
| تدمد: | 1879-6257 |
| DOI: | 10.1016/j.coviro.2014.10.006 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d01cd487bfc1f2799fefac11dc9cd26d https://doi.org/10.1016/j.coviro.2014.10.006 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d01cd487bfc1f2799fefac11dc9cd26d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18796257 |
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| DOI: | 10.1016/j.coviro.2014.10.006 |