Non-invasive MRI quantification of cerebrospinal fluid dynamics in amyotrophic lateral sclerosis patients
| العنوان: | Non-invasive MRI quantification of cerebrospinal fluid dynamics in amyotrophic lateral sclerosis patients |
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| المؤلفون: | Jason Aldred, Bryn A. Martin, Brian Petersen, Tavara Freeman, Kyle McCain, Douglas L. Weeks, Marianne Schmid Daners, Jacob Romm, Dena Wingett, Mohammadreza Khani, Gregory T. Carter, Lucas R. Sass |
| المصدر: | Fluids and Barriers of the CNS, Vol 17, Iss 1, Pp 1-14 (2020) Fluids and Barriers of the CNS, 17 (1) Fluids and Barriers of the CNS |
| بيانات النشر: | ETH Zurich, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, Models, Biological, Subarachnoid Space, lcsh:RC346-429, Cerebrospinal fluid, Amyotrophic lateral sclerosis, Magnetic resonance imaging, Intrathecal drug delivery, Spinal cord, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Developmental Neuroscience, medicine, Humans, Spinal canal, Computer Simulation, lcsh:Neurology. Diseases of the nervous system, 030304 developmental biology, 0303 health sciences, Cerebrospinal fluid dynamics, medicine.diagnostic_test, business.industry, Research, Non invasive, General Medicine, medicine.disease, 3. Good health, medicine.anatomical_structure, Neurology, Sample size determination, Hydrodynamics, Nuclear medicine, business, Spinal Canal, 030217 neurology & neurosurgery |
| الوصف: | Background:Developing novel therapeutic agents to treat amyotrophic lateral sclerosis (ALS) has been difficult due to multifactorial pathophysiologic processes at work. Intrathecal drug administration shows promise due to close proximity of cerebrospinal fluid (CSF) to affected tissues. Development of effective intrathecal pharmaceuticals will rely on accurate models of how drugs are dispersed in the CSF. Therefore, a method to quantify these dynamics and a characterization of differences across disease states is needed. Methods:Complete intrathecal 3D CSF geometry and CSF flow velocities at six axial locations in the spinal canal were collected by T2-weighted and phase-contrast MRI, respectively. Scans were completed for eight people with ALS and ten healthy controls. Manual segmentation of the spinal subarachnoid space was performed and coupled with an interpolated model of CSF flow within the spinal canal. Geometric and hydrodynamic parameters were then gen-erated at 1 mm slice intervals along the entire spine. Temporal analysis of the waveform spectral content and feature points was also completed. Results:Comparison of ALS and control groups revealed a reduction in CSF flow magnitude and increased flow propagation velocities in the ALS cohort. Other differences in spectral harmonic content and geometric comparisons may support an overall decrease in intrathecal compliance in the ALS group. Notably, there was a high degree of vari-ability between cases, with one ALS patient displaying nearly zero CSF flow along the entire spinal canal. Conclusion:While our sample size limits statistical confidence about the differences observed in this study, it was possible to measure and quantify inter-individual and cohort variability in a non-invasive manner. Our study also shows the potential for MRI based measurements of CSF geometry and flow to provide information about the hydro-dynamic environment of the spinal subarachnoid space. These dynamics may be studied further to understand the behavior of CSF solute transport in healthy and diseased states. Fluids and Barriers of the CNS, 17 (1) ISSN:2045-8118 |
| وصف الملف: | application/application/pdf |
| اللغة: | English |
| تدمد: | 2045-8118 |
| DOI: | 10.3929/ethz-b-000392886 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cff1aed6ff2faeab20f5469a1192ebad |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....cff1aed6ff2faeab20f5469a1192ebad |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20458118 |
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| DOI: | 10.3929/ethz-b-000392886 |