Effects of continuous subcutaneous apomorphine infusion in Parkinson's disease without cognitive impairment on motor, cognitive, psychiatric symptoms and quality of life
| العنوان: | Effects of continuous subcutaneous apomorphine infusion in Parkinson's disease without cognitive impairment on motor, cognitive, psychiatric symptoms and quality of life |
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| المؤلفون: | Paul Sauleau, Sophie Drapier, Gabriel Robert, Audrey Riou, Joan Duprez, Marc Vérin, Jean-François Houvenaghel, Dominique Drapier |
| المساهمون: | CHU Pontchaillou [Rennes], Comportement et noyaux gris centraux = Behavior and Basal Ganglia [Rennes], CHU Pontchaillou [Rennes]-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université européenne de Bretagne - European University of Brittany (UEB)-Institut des Neurosciences Cliniques de Rennes (INCR), This research did not receive any specific grant from funding agencies in the public, commercial, or not-for- profit sectors., Université de Rennes (UR)-Université européenne de Bretagne - European University of Brittany (UEB)-CHU Pontchaillou [Rennes]-Institut des Neurosciences Cliniques de Rennes = Institute of Clinical Neurosciences of Rennes (INCR) |
| المصدر: | Journal of the Neurological Sciences Journal of the Neurological Sciences, Elsevier, 2018, 395, pp.113-118. ⟨10.1016/j.jns.2018.10.010⟩ Journal of the Neurological Sciences, 2018, 395, pp.113-118. ⟨10.1016/j.jns.2018.10.010⟩ |
| بيانات النشر: | HAL CCSD, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, medicine.medical_specialty, Parkinson's disease, Apomorphine, Disease, Motor Activity, Neuropsychological Tests, Infusions, Subcutaneous, Severity of Illness Index, Antiparkinson Agents, Levodopa, 03 medical and health sciences, Cognition, 0302 clinical medicine, Quality of life, Severity of illness, medicine, Humans, Psychiatry, Retrospective Studies, business.industry, Mental Disorders, Parkinson Disease, Retrospective cohort study, Middle Aged, medicine.disease, Mental health, 3. Good health, Treatment Outcome, 030104 developmental biology, Neurology, [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, Quality of Life, Drug Therapy, Combination, Female, Neurology (clinical), business, 030217 neurology & neurosurgery, Follow-Up Studies, medicine.drug |
| الوصف: | International audience; INTRODUCTION:Treatment optimization using continuous subcutaneous apomorphine infusion (CSAI) improves the control of motor fluctuations of patients with Parkinson's disease (PD). Although CSAI seems to be cognitively and behaviorally safe and to improve the quality of life, very few studies have investigated its influence in these domains, especially in patients without cognitive impairment.METHODS:We estimated the impact of CSAI on motor symptoms, cognition, psychiatric domains and quality of life in parkinsonian patients without cognitive impairment by comparing the scores of 22 patients assessed before and 6 months after the start of add-on CSAI.RESULTS:Optimized treatment with CSAI was associated with i) reduced motor fluctuations, ii) unchanged cognition, iii) unchanged psychiatric domains, and iv) improved quality of life in physical and psychological aspects.CONCLUSION:In PD patients without cognitive impairment, CSAI improves motor symptoms and quality of life and, as suggested by previous studies, alters neither cognition nor mental health. |
| اللغة: | English |
| تدمد: | 0022-510X |
| DOI: | 10.1016/j.jns.2018.10.010⟩ |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf519fd7e9eb02926ae779dbcd55ec86 https://hal-univ-rennes1.archives-ouvertes.fr/hal-01940272 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....cf519fd7e9eb02926ae779dbcd55ec86 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 0022510X |
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| DOI: | 10.1016/j.jns.2018.10.010⟩ |