Overexpression of peroxiredoxins I, II, III, V, and VI in malignant mesothelioma
| العنوان: | Overexpression of peroxiredoxins I, II, III, V, and VI in malignant mesothelioma |
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| المؤلفون: | Siri Lehtonen, Raija Sormunen, S G Rhee, Ylermi Soini, Sang Won Kang, V L Kinnula, Riitta Kaarteenaho-Wiik |
| المصدر: | Europe PubMed Central |
| بيانات النشر: | Wiley, 2002. |
| سنة النشر: | 2002 |
| مصطلحات موضوعية: | Adult, Male, Mesothelioma, Pathology, medicine.medical_specialty, Pleural Neoplasms, Immunoelectron microscopy, Apoptosis, Biology, medicine.disease_cause, Antioxidants, Pathology and Forensic Medicine, Cytosol, Tumor Cells, Cultured, medicine, Humans, Microscopy, Immunoelectron, Aged, Cell Nucleus, Peroxiredoxins, Middle Aged, medicine.disease, Immunohistochemistry, Molecular biology, Mitochondria, Staining, Peroxidases, Drug Resistance, Neoplasm, Cytoplasm, Case-Control Studies, Pleura, Female, Carcinogenesis, Peroxiredoxin, Peroxiredoxin VI |
| الوصف: | Peroxiredoxins (Prxs) are a recently characterized group of thiol-containing proteins with efficient antioxidant capacity, capable of consuming hydrogen peroxide in living cells. Altogether six distinct Prxs have been characterized in mammalian tissues. Their expression was investigated in histological samples of mesothelioma and in cell lines established from the tumours of mesothelioma patients. Four cases with histopathologically healthy pleura from non-smokers were used as controls. Healthy pleural mesothelium was negative or very weakly positive for all Prxs. In mesothelioma, the most prominent reactivity was observed with Prxs I, II, V, and VI. Prx I was highly or moderately expressed in 25/36 cases, the corresponding figures for Prxs II-VI being 27/36 (Prx II), 13/36 (Prx III), 2/36 (Prx IV), 24/36 (Prx V), and 30/36 (Prx VI). Positive staining was observed both in the cytosolic and the nuclear compartment, with the exception of Prx III, which showed no nuclear reactivity. The staining pattern of Prxs III and V was granular. Immunoelectron microscopic localization of Prxs was in accordance with the immunohistochemical findings, showing diffuse cytoplasmic localization for Prxs I, II, IV, and VI and distinct mitochondrial labelling for Prxs III and V. There was no significant association between the extent of staining and different Prxs. It appeared that Prxs may not have prognostic significance, but being prominently expressed in most mesotheliomas these proteins, at least in theory, may play a role in the primary drug resistance of this disease. |
| تدمد: | 1096-9896 0022-3417 |
| DOI: | 10.1002/path.1042 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf2da5f1d598baebc37be43103717f55 https://doi.org/10.1002/path.1042 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....cf2da5f1d598baebc37be43103717f55 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10969896 00223417 |
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| DOI: | 10.1002/path.1042 |