Uterine Endometrioid Carcinoma with Small Nonvillous Papillae: An Analysis of 26 Cases of a Favorable-Prognosis Tumor To Be Distinguished from Serous Carcinoma
| العنوان: | Uterine Endometrioid Carcinoma with Small Nonvillous Papillae: An Analysis of 26 Cases of a Favorable-Prognosis Tumor To Be Distinguished from Serous Carcinoma |
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| المؤلفون: | Robert H. Young, Robert E. Scully, Shawn K. Murray |
| المصدر: | International Journal of Surgical Pathology. 8:279-289 |
| بيانات النشر: | SAGE Publications, 2000. |
| سنة النشر: | 2000 |
| مصطلحات موضوعية: | 0301 basic medicine, Pathology, medicine.medical_specialty, endocrine system diseases, Serous carcinoma, business.industry, Squamous Differentiation, Uterus, medicine.disease, Villoglandular adenocarcinoma of the cervix, Pathology and Forensic Medicine, 03 medical and health sciences, Serous fluid, 030104 developmental biology, 0302 clinical medicine, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Eosinophilic, medicine, Carcinoma, Surgery, Anatomy, Stage (cooking), business |
| الوصف: | We have encountered a number of endometrioid carcinomas with small papillary buds lacking fibrovascular cores that could be confused with the small cellular papillae of serous papillary carcinoma (SPC). We have designated these tumors "endometrioid carcinoma with small nonvillous papillae" (ECSP). Because they have not been investigated previously we analyzed 26 examples and compared their features with those of 21 SPCs of the uterus. Three hundred and ninety consecutive cases of endometrial carcinoma diagnosed between January, 1989, and January, 1994, were retrieved from our hospital files; 26 (6.7%) of them, (8% of the endometrioid carcinomas) were identified as ECSP, and 21 (5.4%) as SPC. Tumors were classified as ECSP when the small papillae were present within the glands of otherwise typical endometrioid carcinoma or on the villous projections of villoglandular endometrioid carcinoma. Most of the papillae were in the form of buds of cells with ample eosinophilic cytoplasm and a low nuclear-to-cytoplasmic ratio, but some papillae had a more complex pattern. The papillae arose on a background of International Federation of Gynecology and Obstetrics (FIGO) grade 1 or 2 endometrioid carcinomas, which showed squamous differentiation in half the cases. SPCs were identified according to generally accepted criteria. The mean age of the patients with ECSP was 67 years, intermediate between that of the patients with endometrioid carcinoma lacking small nonvillous papillae (62 years) and that of the patients with SPC (71 years). Patients with ECSP more frequently presented at an earlier stage (73% stage I/II) than those with SPC (29% stage I/II). The overall 5-year survival of patients with ECSP was 84% (95%CI: 0.68-1), more than double that of patients with SPC, 33% (95%CI: 0.10-0.56). ECSP may be confused with SPC on microscopic examination but has clinical and pathological features similar to those of endometrioid carcinoma lacking small nonvillous papillae, and unlike SPC, should be treated in the same manner as the former. Int J Surg Pathol 8(4):279-289, 2000 |
| تدمد: | 1940-2465 1066-8969 |
| DOI: | 10.1177/106689690000800407 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf06966a1221cd67ea0d9daf2b9df36c https://doi.org/10.1177/106689690000800407 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....cf06966a1221cd67ea0d9daf2b9df36c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19402465 10668969 |
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| DOI: | 10.1177/106689690000800407 |