Mesenchymal Stem Cell-Derived Exosomes Provide Neuroprotection and Improve Long-Term Neurologic Outcomes in a Swine Model of Traumatic Brain Injury and Hemorrhagic Shock
| العنوان: | Mesenchymal Stem Cell-Derived Exosomes Provide Neuroprotection and Improve Long-Term Neurologic Outcomes in a Swine Model of Traumatic Brain Injury and Hemorrhagic Shock |
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| المؤلفون: | Panpan Chang, Aaron M. Williams, Ye Xiong, Michael Chopp, Yanlu Zhang, Zheng Gang Zhang, Benjamin Buller, Umar F. Bhatti, Kiril Chtraklin, Hasan B. Alam, Vahagn C. Nikolian, Jordana F. Brown, Ihab Halaweish, Isabel S. Dennahy |
| المصدر: | Journal of Neurotrauma. 36:54-60 |
| بيانات النشر: | Mary Ann Liebert Inc, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 030506 rehabilitation, Swine, Traumatic brain injury, Shock, Hemorrhagic, Exosomes, Neuroprotection, 03 medical and health sciences, 0302 clinical medicine, Brain Injuries, Traumatic, Neuroplasticity, medicine, Animals, Preventable death, business.industry, Mesenchymal stem cell, Mesenchymal Stem Cells, Recovery of Function, medicine.disease, Microvesicles, Disease Models, Animal, Hemorrhagic shock, Cancer research, Neurology (clinical), 0305 other medical science, business, 030217 neurology & neurosurgery |
| الوصف: | Combined traumatic brain injury (TBI) and hemorrhagic shock (HS) remains a leading cause of preventable death worldwide. Mesenchymal stem cell-derived exosomes have demonstrated promise in small animal models of neurologic injury. To investigate the effects of exosome treatment in a clinically realistic large animal model, Yorkshire swine underwent TBI and HS. Animals were maintained in shock for 2 h before resuscitation with normal saline (NS). Animals were then resuscitated either with NS (3 × volume of shed blood) or with the same volume of NS with delayed exosome administration (1 × 10 |
| تدمد: | 1557-9042 0897-7151 |
| DOI: | 10.1089/neu.2018.5711 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ced84f85ba0a99b5eba1c5fba92f0af6 https://doi.org/10.1089/neu.2018.5711 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ced84f85ba0a99b5eba1c5fba92f0af6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15579042 08977151 |
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| DOI: | 10.1089/neu.2018.5711 |