Evidence for PTGER4 ,PSCA, and MBOAT7 as risk genes for gastric cancer on the genome and transcriptome level
| العنوان: | Evidence for PTGER4 ,PSCA, and MBOAT7 as risk genes for gastric cancer on the genome and transcriptome level |
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| المؤلفون: | Jesús Espinel, Ines Gockel, Daniela Collette, Thomas Schmidt, Gisela Keller, Katja Butterbach, Yogesh K. Vashist, Martin Kruschewski, Michael Knapp, P. Malfertheiner, Anne C. Böhmer, Angel Lanas, Elisabeth Mangold, Rafael Campo, Oliver Pech, Lutz Hamann, Markus Moehler, Jessica Becker, Aksana Höblinger, Jan Gehlen, Concha Thomson, Maria Asuncion Garcia-Gonzalez, Katharina Weise, Peter P. Grimminger, Hakan Alakus, Hermann Brenner, Hans Lippert, Jakob R. Izbicki, Sebastian J. Hofer, Hauke Lang, Evita Gasenko, Philipp Lingohr, Nicole Kreuser, Timo Hess, Fernando Geijo, Markus M. Nöthen, Marino Venerito, Iurii Krasniuk, Florian Lordick, Michael Vieth, Karsten Ridwelski, Claus Schildberg, Alexander F. Hagel, Christiane J. Bruns, Ralf R. Schumann, Katharina Messerle, Lothar Veits, Johannes Schumacher, Katja Ott, Julia Schröder, Marcis Leja, Vitalia Schüller, Limas Kupčinskas, Federico Sopena, Ernst Rodermann, Juozas Kupcinskas, Nikolaos Vassos, Ángeles Pérez-Aisa, Monika Ludwig, Ugne Gyvyte, Luis Bujanda, Sophie K. M. Heinrichs |
| المصدر: | Cancer Medicine Zaguán. Repositorio Digital de la Universidad de Zaragoza instname |
| بيانات النشر: | Wiley, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Cancer Research, Genotype, Quantitative Trait Loci, eQTL study, Biology, GPI-Linked Proteins, Polymorphism, Single Nucleotide, Genome, Transcriptome, 03 medical and health sciences, Antigens, Neoplasm, Stomach Neoplasms, Gene expression, medicine, Humans, SNP, Genetic Predisposition to Disease, Radiology, Nuclear Medicine and imaging, Gene, Genetic Association Studies, Original Research, Cancer Biology, Genetics, Gene Expression Profiling, Chromosome Mapping, Membrane Proteins, Chromosome, Cancer, medicine.disease, Neoplasm Proteins, Gene Expression Regulation, Neoplastic, 030104 developmental biology, Oncology, genetic association study, Case-Control Studies, Expression quantitative trait loci, gene expression, Chromosomes, Human, Pair 5, Female, Receptors, Prostaglandin E, EP4 Subtype, Acyltransferases, Chromosomes, Human, Pair 8 |
| الوصف: | Genetic associations between variants on chromosome 5p13 and 8q24 and gastric cancer (GC) have been previously reported in the Asian population. We aimed to replicate these findings and to characterize the associations at the genome and transcriptome level. We performed a fine-mapping association study in 1926 GC patients and 2012 controls of European descent using high dense SNP marker sets on both chromosomal regions. Next, we performed expression quantitative trait locus (eQTL) analyses using gastric transcriptome data from 143 individuals focusing on the GC associated variants. On chromosome 5p13 the strongest association was observed at rs6872282 (P = 2.53 x 10(-04)) and on chromosome 8q24 at rs2585176 (P = 1.09 x 10(-09)). On chromosome 5p13 we found cis-eQTL effects with an up-regulation of PTGER4 expression in GC risk allele carrier (P = 9.27 x 10(-11)). On chromosome 8q24 we observed cis-eQTL effects with an upregulation of PSCA expression in GC risk allele carrier (P = 2.17 x 10(-47)). In addition, we found trans-eQTL effects for the same variants on 8q24 with a downregulation of MBOAT7 expression in GC risk allele carrier (P = 3.11 x 10(-09)). In summary, we confirmed and refined the previously reported GC associations at both chromosomal regions. Our data point to shared etiological factors between Asians and Europeans. Furthermore, our data imply an upregulated expression of PTGER4 and PSCA as well as a downregulated expression of MBOAT7 in gastric tissue as risk-conferring GC pathomechanisms. |
| وصف الملف: | application/pdf |
| تدمد: | 2045-7634 |
| DOI: | 10.1002/cam4.1719 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cec9666338eed5d98bfda531e28ffdd9 https://doi.org/10.1002/cam4.1719 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....cec9666338eed5d98bfda531e28ffdd9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20457634 |
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| DOI: | 10.1002/cam4.1719 |