Drug-resistant epilepsy at the age extremes: Disentangling the underlying etiology
| العنوان: | Drug-resistant epilepsy at the age extremes: Disentangling the underlying etiology |
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| المؤلفون: | Emanuele Bartolini, Anna Rita Ferrari, Simona Lattanzi, Silvia Pradella, Gaetano Zaccara |
| المصدر: | Epilepsybehavior : EB. 132 |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Behavioral Neuroscience, Drug Resistant Epilepsy, Epilepsy, Neurology, Humans, Electroencephalography, Epilepsy, Generalized, Neurology (clinical), Epilepsies, Partial, Syndrome, Child, Aged |
| الوصف: | PMID:35636351 DOI:10.1016/j.yebeh.2022.108739 The incidence of epilepsy is highest at the extreme age ranges: childhood and elderly age. The most common syndromes in these demographics - self-limited epilepsies of childhood and idiopathic generalized epilepsies in pediatric age, focal epilepsy with structural etiology in older people - are expected to be drug responsive. In this work, we focus on such epilepsy types, overviewing the complex clinical background of unexpected drug-resistance. For self-limited epilepsies of childhood and idiopathic generalized epilepsies, we illustrate drug-resistance resulting from syndrome misinterpretation, reason on possible unexpected courses of epilepsy, and explicate the influence of inappropriate treatments. For elderly-onset epilepsy, we show the challenges in differential diagnosis possibly leading to pseudoresistance and analyze how drug-resistant epilepsy can arise in stroke, neurocognitive disorders, brain tumors, and autoimmune encephalitis. In children and senior people, drug-resistance can be regarded as a hint to review the diagnosis or explore alternative therapeutic strategies. Refractory seizures are not only a therapeutic challenge, but also a cardinal sign not to be overlooked in syndromes commonly deemed to be drug-responsive. |
| تدمد: | 1525-5069 3563-6351 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce845f3cfd8b428a45ddff611c0e2150 https://pubmed.ncbi.nlm.nih.gov/35636351 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....ce845f3cfd8b428a45ddff611c0e2150 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15255069 35636351 |
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