Dopamine neuron-derived IGF-1 controls dopamine neuron firing, skill learning, and exploration
| العنوان: | Dopamine neuron-derived IGF-1 controls dopamine neuron firing, skill learning, and exploration |
|---|---|
| المؤلفون: | Siew-Lan Ang, François Guillemot, Stephanie J. Cragg, Emanuel F. Lopes, Alessandro Pristerà, Sarah Threlfell, Elisa Merlini, Craig Blomeley, Denis Burdakov |
| المصدر: | Proceedings of the National Academy of Sciences of the United States of America |
| بيانات النشر: | National Academy of Sciences, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_treatment, Regulator, Neuropeptide, IFG-1, firing, behavior, dopamine, somatodendritic, Striatum, Biology, Midbrain, Mice, 03 medical and health sciences, Cognition, 0302 clinical medicine, Mesencephalon, Dopamine, medicine, Animals, Learning, Insulin-Like Growth Factor I, Multidisciplinary, Dopaminergic Neurons, Growth factor, Neuropeptides, Depolarization, Biological Sciences, Corpus Striatum, Hormones, 3. Good health, 030104 developmental biology, medicine.anatomical_structure, PNAS Plus, nervous system, Exploratory Behavior, IGF-1, Neuron, Neuroscience, Locomotion, 030217 neurology & neurosurgery, medicine.drug |
| الوصف: | Significance Midbrain dopamine neurons play a role in motivational and cognitive control of behavior. In addition, they regulate motor functions. Dysregulation of dopamine neurons has been linked to depression, schizophrenia, and addiction and their degeneration is causal to Parkinson’s disease. Peripheral hormones have been shown to regulate dopamine neurons functions. Insulin-like growth factor 1 (IGF-1) is a hormone mainly produced in the liver. With this study we discovered that midbrain dopamine neurons synthesize and release IGF-1 in an activity dependent manner. In addition, dopamine neuron-derived IGF-1 modulates dopamine synthesis and dopamine neuron firing and ultimately it controls dopamine-dependent behaviors. This study highlights the neuromodulatory role of neuron-derived IGF-1 and its role in shaping dopamine transmission in the brain. Midbrain dopamine neurons, which can be regulated by neuropeptides and hormones, play a fundamental role in controlling cognitive processes, reward mechanisms, and motor functions. The hormonal actions of insulin-like growth factor 1 (IGF-1) produced by the liver have been well described, but the role of neuronally derived IGF-1 remains largely unexplored. We discovered that dopamine neurons secrete IGF-1 from the cell bodies following depolarization, and that IGF-1 controls release of dopamine in the ventral midbrain. In addition, conditional deletion of dopamine neuron-derived IGF-1 in adult mice leads to decrease of dopamine content in the striatum and deficits in dopamine neuron firing and causes reduced spontaneous locomotion and impairments in explorative and learning behaviors. These data identify that dopamine neuron-derived IGF-1 acts as a regulator of dopamine neurons and regulates dopamine-mediated behaviors. |
| وصف الملف: | application/application/pdf |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdb6d764efdbc238429b7f7949abd863 https://hdl.handle.net/20.500.11850/394508 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....cdb6d764efdbc238429b7f7949abd863 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |