Periodontal diseases and depression: A pre‐clinical in vivo study
| العنوان: | Periodontal diseases and depression: A pre‐clinical in vivo study |
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| المؤلفون: | Karina S. Mac-Dowell, Nagore Ambrosio, Mariano Sanz, Juan C. Leza, Eduardo Montero, María José Marín, Elena Figuero, Álvaro González-Bris, David Martín-Hernández, Borja García-Bueno, M. I. Martínez, David Herrera, Leire Virto |
| المصدر: | Journal of Clinical Periodontology. 48:503-527 |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, Inflammation, 03 medical and health sciences, 0302 clinical medicine, Glucocorticoid receptor, In vivo, Internal medicine, Animals, Medicine, 030212 general & internal medicine, Rats, Wistar, Porphyromonas gingivalis, Periodontal Diseases, Dental alveolus, Neuroinflammation, Periodontitis, Fusobacterium nucleatum, biology, Depression, business.industry, 030206 dentistry, biology.organism_classification, medicine.disease, Rats, Endocrinology, Periodontics, medicine.symptom, business |
| الوصف: | Aim To analyse, through a pre-clinical in vivo model, the possible mechanisms linking depression and periodontitis at behavioural, microbiological and molecular levels. Materials and methods Periodontitis (P) was induced in Wistar:Han rats (oral gavages with Porphyromonas gingivalis and Fusobacterium nucleatum) during 12 weeks, followed by a 3-week period of Chronic Mild Stress (CMS) induction. Four groups (n = 12 rats/group) were obtained: periodontitis and CMS (P+CMS+); periodontitis without CMS; CMS without periodontitis; and control. Periodontal clinical variables, alveolar bone levels (ABL), depressive-like behaviour, microbial counts and expression of inflammatory mediators in plasma and brain frontal cortex (FC), were measured. ANOVA tests were applied. Results The highest values for ABL occurred in the P+CMS+ group, which also presented the highest expression of pro-inflammatory mediators (TNF-α, IL-1β and NF-kB) in frontal cortex, related to the lipoprotein APOA1-mediated transport of bacterial lipopolysaccharide to the brain and the detection of F. nucleatum in the brain parenchyma. A dysregulation of the hypothalamic-pituitary-adrenal stress axis, reflected by the increase in plasma corticosterone and glucocorticoid receptor levels in FC, was also found in this group. Conclusions Neuroinflammation induced by F. nucleatum (through a leaky mouth) might act as the linking mechanism between periodontal diseases and depression. |
| تدمد: | 1600-051X 0303-6979 |
| DOI: | 10.1111/jcpe.13420 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd221f8e4b0c675f508830393ee7a7a5 https://doi.org/10.1111/jcpe.13420 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....cd221f8e4b0c675f508830393ee7a7a5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1600051X 03036979 |
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| DOI: | 10.1111/jcpe.13420 |