Possibilities for the Use of Autologous Mesenchymal Stem Cells in the Therapy of Radiation-Induced Lung Injuries
| العنوان: | Possibilities for the Use of Autologous Mesenchymal Stem Cells in the Therapy of Radiation-Induced Lung Injuries |
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| المؤلفون: | L. V. Kursova, M. V. Poluektova, O. A. Konoplyannikova, I. N. Ivanova, A. G. Konoplyannikov, V. V. Pasov |
| المصدر: | Bulletin of Experimental Biology and Medicine. 147:542-546 |
| بيانات النشر: | Springer Science and Business Media LLC, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Adult, Male, Pathology, medicine.medical_specialty, medicine.medical_treatment, Pilot Projects, Lung injury, Mesenchymal Stem Cell Transplantation, Transplantation, Autologous, General Biochemistry, Genetics and Molecular Biology, Cell therapy, Mice, medicine, Animals, Humans, Radiation Injuries, Lung, Radiotherapy, business.industry, Mesenchymal stem cell, Combination chemotherapy, Lung Injury, General Medicine, Mice, Inbred C57BL, Radiation Pneumonitis, Radiation therapy, Transplantation, Clinical trial, Radiation Injuries, Experimental, Treatment Outcome, medicine.anatomical_structure, Disease Progression, business |
| الوصف: | Possible therapeutic effect of systemic (intravenous) transplantation of autologous mesenchymal stem cells was studied in experiments (C57Bl/6 mice) and pilot clinical trial. Clinical trial was performed on 11 patients with radiation-induced lung injuries developed after combined chemotherapy and radiation therapy for lymphogranulomatosis or breast cancer. The patients were subjected to single transplantation of mesenchymal stem cells and course of standard pharmacotherapy. The method for isolation of autologous mesenchymal stem cells was licensed. The transplantation of mesenchymal stem cells was followed by a decrease in the mortality rate of mice with radiation-induced lung injury. Clinical trial showed that cell therapy with autologous mesenchymal stem cells does not induce progression of the underlying oncological disease. Parameters of spirography, immune status, lung scintigraphy, and markers for inflammation and tissue hypoxia in the patients remained practically unchanged 1 year after the treatment. These clinical signs reflect stabilization of the radiation process. |
| تدمد: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-009-0538-7 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccdfab81f6031f9c3b3824426328c9d4 https://doi.org/10.1007/s10517-009-0538-7 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....ccdfab81f6031f9c3b3824426328c9d4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15738221 00074888 |
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| DOI: | 10.1007/s10517-009-0538-7 |