Fusaricidins, Polymyxins and Volatiles Produced by Paenibacillus polymyxa Strains DSM 32871 and M1
| العنوان: | Fusaricidins, Polymyxins and Volatiles Produced by Paenibacillus polymyxa Strains DSM 32871 and M1 |
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| المؤلفون: | Joachim Vater, Elisa Schwarz, Jennifer Jähne, Kristin Dietel, Stefanie Herfort, Peter Lasch, Tomislav Cernava, Gabriele Berg, Pascal Mülner |
| المصدر: | Pathogens Pathogens, Vol 10, Iss 1485, p 1485 (2021) Volume 10 Issue 11 |
| بيانات النشر: | Preprints, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Microbiology (medical), Antifungal, medicine.drug_class, Polymyxin, Antibiotics, GC���MS, Article, Microbiology, chemistry.chemical_compound, medicine, P. polymyxa, Immunology and Allergy, GC–MS, ddc:610, Molecular Biology, General Immunology and Microbiology, biology, Strain (chemistry), microbiology, MALDI-TOF mass spectrometry, Lipopeptide, biology.organism_classification, MALDI-TOF Mass Spectrometry, Infectious Diseases, volatiles, chemistry, Medicine, Paenibacillus polymyxa, 610 Medizin und Gesundheit, bioactive peptides, Bacteria |
| الوصف: | Paenibacilli are efficient producers of potent agents against bacterial and fungal pathogens, which are of great interest both for therapeutic applications in medicine as well as in agrobiotechnology. Lipopeptides produced by such organisms play a major role in their potential to inactivate pathogens. In this work we investigated two lipopeptide complexes, the fusaricidins and the polymyxins, produced by Paenibacillus polymyxa strains DSM 32871 and M1 by MALDI-TOF mass spectrometry. The fusaricidins show potent antifungal activities and are distinguished by an unusual variability. For strain DSM 32871 we identified numerous yet unknown variants mass spectrometrically. DSM 32871 produces polymyxins of type E (colistins), while M1 forms polymyxins P. For both strains, novel but not yet completely characterized polymyxin species were detected, which possibly are glycosylated. These compounds may be of interest therapeutically, because polymyxins have gained increasing attention as last-resort antibiotics against multiresistant pathogenic Gram-negative bacteria. In addition, the volatilomes of DSM 32781 and M1 were investigated with a GC–MS approach using different cultivation media. Production of volatile organic compounds (VOCs) was strain and medium dependent. In particular, strain M1 manifested as an efficient VOC-producer that exhibited formation of 25 volatiles in total. A characteristic feature of Paenibacilli is the formation of volatile pyrazine derivatives. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| DOI: | 10.0268/v1 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccb7a34dd2c5366ab7b5399b1300cb8e |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ccb7a34dd2c5366ab7b5399b1300cb8e |
| قاعدة البيانات: | OpenAIRE |
| DOI: | 10.0268/v1 |
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