Hypertension: a new treatment for an old disease? Targeting the immune system
| العنوان: | Hypertension: a new treatment for an old disease? Targeting the immune system |
|---|---|
| المؤلفون: | Fernando S. Carneiro, Alexandre Santos Bruno, Stefany Bruno de Assis Cau, Aline Garcia Fedoce, Gisele Facholi Bomfim |
| المصدر: | Br J Pharmacol Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| بيانات النشر: | John Wiley and Sons Inc., 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Pharmacology, medicine.medical_specialty, business.industry, SISTEMA IMUNE, Conventional treatment, Context (language use), Disease, Clinical trial, Pathogenesis, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Immune system, Immune System, Hypertension, Medicine, Animals, Humans, business, Intensive care medicine, 030217 neurology & neurosurgery, Antihypertensive Agents, Themed Section: Review Article |
| الوصف: | Arterial hypertension represents a serious public health problem, being a major cause of morbidity and mortality worldwide. The availability of many antihypertensive therapeutic strategies still fails to adequately treat around 20% of hypertensive patients, who are considered resistant to conventional treatment. In the pathogenesis of hypertension, immune system mechanisms are activated and both the innate and adaptive immune responses play a crucial role. However, what, when and how the immune system is triggered during hypertension development is still largely undefined. In this context, this review highlights scientific advances in the manipulation of the immune system in order to attenuate hypertension and end-organ damage. Here, we discuss the potential use of immunosuppressants and immunomodulators as pharmacological tools to control the activation of the immune system, by non-specific and specific mechanisms, to treat hypertension and improve end-organ damage. Nevertheless, more clinical trials should be performed with these drugs to establish their therapeutic efficacy, safety and risk-benefit ratio in hypertensive conditions. LINKED ARTICLES: This article is part of a themed section on Immune Targets in Hypertension. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.12/issuetoc. |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc9242b902dac4613530d8ee0d2de536 https://europepmc.org/articles/PMC6534786/ |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....cc9242b902dac4613530d8ee0d2de536 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |