A Topologically Distinct Modified Peptide with Multiple Bicyclic Core Motifs Expands the Diversity of Microviridin‐Like Peptides
| العنوان: | A Topologically Distinct Modified Peptide with Multiple Bicyclic Core Motifs Expands the Diversity of Microviridin‐Like Peptides |
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| المؤلفون: | Seokhee Kim, Heejin Roh, Yeji Han, Hyunbin Lee |
| المصدر: | ChemBioChem. 20:1051-1059 |
| بيانات النشر: | Wiley, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | chemistry.chemical_classification, Bicyclic molecule, 010405 organic chemistry, Stereochemistry, Organic Chemistry, Esters, Peptide, 010402 general chemistry, Ring (chemistry), Peptides, Cyclic, 01 natural sciences, Biochemistry, 0104 chemical sciences, chemistry, Core (graph theory), Side chain, Consensus sequence, Molecular Medicine, Amino Acid Sequence, Protein Processing, Post-Translational, Molecular Biology |
| الوصف: | Microviridins are ribosomally synthesized and post-translationally modified peptides (RiPPs) that contain multiple intramolecular ω-ester or ω-amide crosslinks between two side chains in peptides. This type of the side-to-side macrocyclization may generate diverse structures with distinct topology and ring sizes, but the majority of the microviridin-like RiPPs present only a single consensus sequence with a tricyclic architecture. Here, we expanded the natural diversity of the microviridin-like modified peptides by determining the crosslinking connectivity of a new modified peptide, mTgnA and its homologous RiPPs, which we named the thuringinin group. Members of the thuringinin group have core motifs with a distinct consensus sequence, which is transformed to a novel hairpin-like bicyclic structure by the cognate ATP-grasp enzyme. We suggest that the microviridin-like RiPPs naturally have novel sequences and architectures beyond those found in microviridins and comprise a larger RiPP family, termed omega-ester containing peptides (OEPs). |
| تدمد: | 1439-7633 1439-4227 |
| DOI: | 10.1002/cbic.201800678 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb38ef017b4fc9074796bf8edf938cd2 https://doi.org/10.1002/cbic.201800678 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....cb38ef017b4fc9074796bf8edf938cd2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14397633 14394227 |
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| DOI: | 10.1002/cbic.201800678 |