Encephalitozoon cuniculi Genotype III Evinces a Resistance to Albendazole Treatment in both Immunodeficient and Immunocompetent Mice
| العنوان: | Encephalitozoon cuniculi Genotype III Evinces a Resistance to Albendazole Treatment in both Immunodeficient and Immunocompetent Mice |
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| المؤلفون: | Klára Brdíčková, Dana Květoňová, Nikola Holubová, Bohumil Sak, Lenka Hlásková, Martin Kváč |
| المصدر: | Antimicrob Agents Chemother |
| بيانات النشر: | American Society for Microbiology, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Antifungal Agents, Genotype, CD8 Antigens, Colony Count, Microbial, Mice, SCID, Microbial Sensitivity Tests, Albendazole, Microsporidiosis, Asymptomatic, Cell Line, Microbiology, Immunocompromised Host, Mice, 03 medical and health sciences, Chlorocebus aethiops, parasitic diseases, medicine, Animals, Parasite hosting, Experimental Therapeutics, Pharmacology (medical), Vero Cells, Encephalitozoon cuniculi, 030304 developmental biology, Mice, Knockout, Pharmacology, Mice, Inbred BALB C, 0303 health sciences, biology, 030306 microbiology, fungi, virus diseases, medicine.disease, biology.organism_classification, Spore, Mice, Inbred C57BL, Disease Models, Animal, Infectious Diseases, CD4 Antigens, Microsporidia, Encephalitozoonosis, medicine.symptom, medicine.drug |
| الوصف: | Of four genotypes of Encephalitozoon cuniculi, E. cuniculi genotype II is considered to represent a parasite that occurs in many host species in a latent asymptomatic form, whereas E. cuniculi genotype III seems to be more aggressive, and infections caused by this strain can lead to the death of even immunocompetent hosts. Although albendazole has been considered suitable for treatment of Encephalitozoon species, its failure in control of E. cuniculi genotype III infection has been reported. This study determined the effect of a 100× recommended daily dose of albendazole on an Encephalitozoon cuniculi genotype III course of infection in immunocompetent and immunodeficient mice and compared the results with those from experiments performed with a lower dose of albendazole and E. cuniculi genotype II. The administration of the regular dose of abendazole during the acute phase of infection reduced the number of affected organs in all strains of mice and absolute counts of spores in screened organs. However, the effect on genotype III was minor. Surprisingly, no substantial effect was recorded after the use of a 100× dose of albendazole, with larger reductions seen only in the number of affected organs and absolute counts of spores in all strains of mice, implying variations in albendazole resistance between these Encephalitozoon cuniculi genotypes. These results imply that differences in the course of infection and the response to treatment depend not only on the immunological status of the host but also on the genotype causing the infection. Understanding how microsporidia survive in hosts despite targeted antimicrosporidial treatment could significantly contribute to research related to human health. |
| تدمد: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.00058-20 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb050dbc482bdd83f10bf81c77b0b38c https://doi.org/10.1128/aac.00058-20 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....cb050dbc482bdd83f10bf81c77b0b38c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10986596 00664804 |
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| DOI: | 10.1128/aac.00058-20 |