Does Pepsin Saliva Concentration (Peptest™) Predict the Therapeutic Response of Laryngopharyngeal Reflux Patients?
| العنوان: | Does Pepsin Saliva Concentration (Peptest™) Predict the Therapeutic Response of Laryngopharyngeal Reflux Patients? |
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| المؤلفون: | Charelle Salem, Sven Saussez, Vinciane Muls, Marie Paule Thill, Serge D Le Bon, Mihaela Horoi, Francois Bobin, Jerome R. Lechien, Didier Dequanter, Alexandra Rodriguez |
| المساهمون: | Université de Versailles Saint-Quentin-en-Yvelines - UFR Sciences de la santé Simone Veil (UVSQ Santé), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Hôpital Foch [Suresnes], ELSAN-Polyclinique de Poitiers, CHU Saint-Pierre, Université libre de Bruxelles (ULB), Vesale Grant & IRIS-Recherche Grant (Foundation Roi Baudouin). The author(s) received no financial support for the research, authorship, and/or publication of this article. |
| المصدر: | Annals of Otology Rhinology and Laryngology Annals of Otology Rhinology and Laryngology, SAGE Publications, 2021, 130 (9), pp.996-1003. ⟨10.1177/0003489420986347⟩ |
| بيانات النشر: | HAL CCSD, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, Saliva, Aluminum Hydroxide, Laryngitis, Gastroenterology, Laryngopharyngeal reflux, 0302 clinical medicine, Pepsin, [SHS.LANGUE]Humanities and Social Sciences/Linguistics, 030223 otorhinolaryngology, profile, biology, treatment, General Medicine, Hydrogen-Ion Concentration, Middle Aged, pharyngeal, Prognosis, 3. Good health, 030220 oncology & carcinogenesis, Female, Antacids, Adult, medicine.medical_specialty, Esophageal pH Monitoring, Magnesium Hydroxide, Alginates, reflux episode, Ph monitoring, 03 medical and health sciences, Esophagus, Internal medicine, medicine, Laryngopharyngeal Reflux, Humans, laryngitis, Aged, Monitoring, Physiologic, pepsin, business.industry, pH monitoring, Reflux, Proton Pump Inhibitors, medicine.disease, Pepsin A, laryngopharyngeal, Hypopharynx, Diagnostic Techniques, Digestive System, Otorhinolaryngology, impedance, biology.protein, reflux, business, Diet Therapy |
| الوصف: | Objective: To study the profile and the therapeutic response of patients with laryngopharyngeal reflux (LPR) at the hypopharyngeal-esophageal multichannel intraluminal impedance-pH monitoring (HEMII-pH) according to the initial pepsin saliva concentration. Methods: From January 2018 to January 2020, patients with positive LPR diagnosis at the HEMII-pH were consecutively recruited from 3 European Hospitals. Saliva pepsin concentration (Peptest™) was measured during the HEMII-pH testing period and patients were classified into 2 groups: negative versus positive Peptest. The clinical outcomes, that is, gastrointestinal and HEMII-pH findings, reflux symptom score-12 (RSS-12), and 3-month therapeutic response, were compared between groups. Results: A total of 124 patients completed the study. Among them, 30 patients had negative Peptest. Pharyngeal reflux events occurred outside 1-hour post-meal time in 74.0%, after the meals in 20.5% and nighttime in 5.5%. The pepsin saliva level was not significantly associated with the reflux events preceding the sample collection. Patients with positive Peptest had better improvement of RSS-12 digestive and respiratory subscores and oral, pharyngeal, and laryngeal findings compared with patients with negative Peptest. Conclusion: Patients with high saliva pepsin concentration had no stronger gastrointestinal, HEMII-pH, or clinical outcomes compared with those with low or undetectable saliva pepsin concentration. |
| اللغة: | English |
| تدمد: | 0003-4894 1943-572X |
| DOI: | 10.1177/0003489420986347⟩ |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cadb72bd3bd7c9f9aba8efd8f7c73add https://hal.archives-ouvertes.fr/hal-03401798 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....cadb72bd3bd7c9f9aba8efd8f7c73add |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00034894 1943572X |
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| DOI: | 10.1177/0003489420986347⟩ |