Mechanism of interaction between cisplatin and human recombinant interferon gamma in human ovarian-cancer cell lines
| العنوان: | Mechanism of interaction between cisplatin and human recombinant interferon gamma in human ovarian-cancer cell lines |
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| المؤلفون: | Sylvie Guichard, Marie Josée Caliaro, Anne-Marie Julia, Pierre Canal, Nicolas Albin, Alissar Nehmé, Suzanne Jozan, Roland Bugat |
| المصدر: | International Journal of Cancer. 61:643-648 |
| بيانات النشر: | Wiley, 1995. |
| سنة النشر: | 1995 |
| مصطلحات موضوعية: | Cancer Research, medicine.medical_specialty, DNA Repair, DNA repair, medicine.medical_treatment, Gene Expression, Biology, law.invention, Interferon-gamma, chemistry.chemical_compound, law, Internal medicine, Tumor Cells, Cultured, medicine, Humans, Interferon gamma, RNA, Messenger, Ovarian Neoplasms, Cisplatin, Recombinant Interferon Gamma, Glutathione, Genes, erbB-2, Recombinant Proteins, Cytokine, Endocrinology, Oncology, chemistry, Cell culture, Recombinant DNA, Cancer research, Female, Metallothionein, DNA Damage, medicine.drug |
| الوصف: | Human ovarian carcinoma cells (2008 and its cisplatin-resistant sub-line 2008/C13*) were sensitized to cisplatin by treatment with human recombinant gamma interferon (IFN gamma). IFN gamma produced no significant change in the uptake of CDDP. Exposure of 2008 and 2008/C13* cells to IFN gamma resulted in a time-dependent decrease of cellular glutathione and total glutathione-S-transferase activity, principally the pi isoform. By contrast, the treatment of 2008 and 2008/C13* cell lines with IFN gamma induced rather than suppressed metallothionein IIA mRNA levels. IFN gamma changed neither the formation of total platinum-DNA adducts, nor DNA repair. A significant decrease in c-erbB-2 expression was observed both in sensitive and in resistant cell lines after treatment with IFN gamma, and this decrease was dose-dependent. Our results indicate that the mechanism of IFN gamma-induced sensitization in human ovarian-cancer cell lines is multifactorial. |
| تدمد: | 1097-0215 0020-7136 |
| DOI: | 10.1002/ijc.2910610510 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca3bf789371a01bb952f77dcbaa3277e https://doi.org/10.1002/ijc.2910610510 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....ca3bf789371a01bb952f77dcbaa3277e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10970215 00207136 |
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| DOI: | 10.1002/ijc.2910610510 |