Noise stress changes mRNA expressions of corticotropin-releasing hormone, its receptors in amygdala, and anxiety-related behaviors
| العنوان: | Noise stress changes mRNA expressions of corticotropin-releasing hormone, its receptors in amygdala, and anxiety-related behaviors |
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| المؤلفون: | Ibrahim Akyazi, Erg L-Ekiz E, Erdal Matur, Evren Eraslan |
| المصدر: | Noise & Health Noise and Health, Vol 17, Iss 76, Pp 141-147 (2015) |
| بيانات النشر: | Medknow Publications & Media Pvt Ltd, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, endocrine system, Corticotropin-Releasing Hormone, Anxiety, Amygdala, Receptors, Corticotropin-Releasing Hormone, Rats, Sprague-Dawley, lcsh:RC963-969, Speech and Hearing, Corticotropin-releasing hormone, Downregulation and upregulation, Internal medicine, medicine, Animals, Chronic stress, RNA, Messenger, Receptor, corticotropin-releasing hormone (CRH) system molecules, noise stress, Environmental stressor, Public Health, Environmental and Occupational Health, lcsh:Otorhinolaryngology, lcsh:RF1-547, anxiety behaviors, medicine.anatomical_structure, Endocrinology, Otorhinolaryngology, nervous system, lcsh:Industrial medicine. Industrial hygiene, Original Article, medicine.symptom, Psychology, Noise, hormones, hormone substitutes, and hormone antagonists, Hormone |
| الوصف: | Noise is a psychological, environmental stressor that activates limbic sites in the brain. Limbic sites such as the amygdala and the amygdaloid corticotropin-releasing hormone (CRH) system play an important role in integrating stress response. We investigated the association between noise exposures, CRH-related molecules in the amygdala, and behavioral alterations. In total 54 Sprague-Dawley rats were divided into the following three groups: Control (CON), acute noise exposure (ANE), and chronic noise exposure (CNE). The ANE group was exposed to 100 dB white noise only once in 4 h and the CNE group was exposed to the same for 4 h per day for 30 days. Expression profiles of CRH and its receptors CRH-R1 and CRH-R2 were analyzed by quantitative real-time polymerase chain reaction (qPCR). The same stress procedure was applied to the ANE and CNE groups for behavior testing. The anxiety responses of the animals after acute and chronic stress exposure were measured in the defensive withdrawal test. CNE upregulated CRH and CRH-R1 mRNA levels but downregulated CRH-R2 mRNA levels. ANE led to a decrease in both CRH-R1 and CRH-R2 expression. In the defensive withdrawal test, while the ANE increased, CNE reduced anxiety-like behaviors. The present study shows that the exposure of rats to white noise (100 dB) leads to behavioral alterations and molecule-specific changes in the CRH system. Behavioral alterations can be related to these molecular changes in the amygdala. |
| اللغة: | English |
| تدمد: | 1998-4030 1463-1741 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca35eac363ceb59d3c64db04d8df64c7 http://europepmc.org/articles/PMC4918649 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ca35eac363ceb59d3c64db04d8df64c7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19984030 14631741 |
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