Preclinical Toxicological Study of Release-Active Preparations for Prediction of Their Pharmacological Activity and Side Effects
| العنوان: | Preclinical Toxicological Study of Release-Active Preparations for Prediction of Their Pharmacological Activity and Side Effects |
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| المؤلفون: | E. S. Zhavbert, V. I. Petrov, L. I. Bugaeva, O. I. Epshtein, S. A. Lebedeva, N. N. Yakovleva, Yu. L. Dugina, E. I. Surkova |
| المصدر: | Bulletin of Experimental Biology and Medicine. 161:252-256 |
| بيانات النشر: | Springer Science and Business Media LLC, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Cannabinoid receptor, Drug Evaluation, Preclinical, Motor Activity, Pharmacology, Antibodies, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, 0302 clinical medicine, Appetite Depressants, Animals, Receptor, Chronic toxicity, biology, Chemistry, Body Weight, Biological activity, General Medicine, Angiotensin II, Rats, 030104 developmental biology, biology.protein, Female, Antibody, 030217 neurology & neurosurgery |
| الوصف: | We studied chronic toxicity of a few release-active preparations: Dietressa (release-active preparation of affinity-purified antibodies to type 1 cannabinoid receptor), Divasa (releaseactive preparation containing a combination of affinity-purified antibodies to brain-specific S-100 protein and endothelial NO-synthase), Cardostin (release-active preparation containing a combination of affinity-purified antibodies to C-terminal fragment of angiotensin II type 1 receptor and endothelial NO-synthase), and Bation (release-active preparation containing a combination of affinity-purified antibodies to IFN-γ and CD4). We evaluated not only side and toxic effects, but also the relationships between these effects and pharmacological activities of the preparations. The data of preclinical toxicological studies of the release-active preparations can be used for prediction of their pharmacological activity. |
| تدمد: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-016-3389-z |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9d97170ced0d7f158b2f9d763edf329 https://doi.org/10.1007/s10517-016-3389-z |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....c9d97170ced0d7f158b2f9d763edf329 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15738221 00074888 |
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| DOI: | 10.1007/s10517-016-3389-z |