A tale of two lipids: Lipid unsaturation commands ferroptosis sensitivity
| العنوان: | A tale of two lipids: Lipid unsaturation commands ferroptosis sensitivity |
|---|---|
| المؤلفون: | Jason Rodencal, Scott J. Dixon |
| المصدر: | PROTEOMICS. 23:2100308 |
| بيانات النشر: | Wiley, 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Molecular Biology, Biochemistry |
| الوصف: | Membrane lipids play important roles in the regulation of cell fate, including the execution of ferroptosis. Ferroptosis is a non-apoptotic cell death mechanism defined by iron-dependent membrane lipid peroxidation. Phospholipids containing polyunsaturated fatty acids (PUFAs) are highly vulnerable to peroxidation and are essential for ferroptosis execution. By contrast, the incorporation of less oxidizable monounsaturated fatty acids (MUFAs) in membrane phospholipids protects cells from ferroptosis. The enzymes and pathways that govern PUFA and MUFA metabolism therefore play a critical role in determining cellular sensitivity to ferroptosis. Here, we review three lipid metabolic processes fatty acid biosynthesis, ether lipid biosynthesis, and phospholipid remodeling-that govern ferroptosis sensitivity by regulating the balance of PUFAs and MUFAs in membrane phospholipids. This article is protected by copyright. All rights reserved. |
| تدمد: | 1615-9861 1615-9853 |
| DOI: | 10.1002/pmic.202100308 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9af7fb963b1e348a439a13ed11b2233 https://doi.org/10.1002/pmic.202100308 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....c9af7fb963b1e348a439a13ed11b2233 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16159861 16159853 |
|---|---|
| DOI: | 10.1002/pmic.202100308 |