High vancomycin MICs predict the development of infective endocarditis in patients with catheter-related bacteraemia due to methicillin-resistant Staphylococcus aureus
| العنوان: | High vancomycin MICs predict the development of infective endocarditis in patients with catheter-related bacteraemia due to methicillin-resistant Staphylococcus aureus |
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| المؤلفون: | Jesús Rodríguez-Baño, Mariana Camoez, Álvaro Pascual Hernández, Miquel Pujol, Juan Pablo Horcajada, Esther Calbo, RAFAEL SAN-JUAN, Natividad Benito, Jose A. Lepe, M. Angeles Domínguez, Benito Almirante, Francisco Lopez-Medrano |
| المساهمون: | Ministerio de Economía y Competitividad (España), Instituto de Salud Carlos III, European Commission, Red Española de Investigación en Patología Infecciosa |
| المصدر: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| بيانات النشر: | Oxford University Press, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, Microbiology (medical), medicine.medical_specialty, Catheters, Bacterial endocarditis, 030106 microbiology, Bacteremia, Microbial Sensitivity Tests, medicine.disease_cause, Young Adult, 03 medical and health sciences, Disk Diffusion Antimicrobial Tests, Risk Factors, Vancomycin, Antibiotic therapy, medicine, Humans, Pharmacology (medical), In patient, Prospective Studies, Mortality, Aged, Pharmacology, Endocarditis, Middle Aged, Staphylococcal Infections, Methicillin-resistant Staphylococcus aureus, Anti-Bacterial Agents, Surgery, Malnutrition-inflammation-cachexia syndrome, Infectious Diseases, Geography, Catheter-Related Infections, Regression Analysis, Methicillin-resistant staphylococcus aureus, Female, Humanities |
| الوصف: | REIPI/GEIH Study Group: A. Jover, F. Barcenilla, M. García (Hospital ‘Arnau de Vilanova’, Lleida, Spain); M. Pujol, O. Gasch, M.A. Domínguez, M. Camoez (Hospital Universitari de Bellvitge, L’Hospitalet de Llobregat, Barcelona, Spain); C. Dueñas, E. Ojeda (Hospital Universitario de Burgos, Burgos, Spain); J. A. Martinez, F. Marco (Hospital Clinic, Barcelona, Spain); F. Chaves, M. Fernández-Ruiz, M. Lagarde, F. López-Medrano, J. M. Aguado (Hospital Universitario ‘12 de Octubre’, Madrid, Spain); J. M. Montejo, E. Bereciartua, J. L. Hernández (Hospital de Cruces, Barakaldo, Spain); M. A. Von Wichmann, A. Goenaga, J. M. García-Arenzana (Hospital de Donostia, Donostia, Spain); B. Padilla, C. Padilla, E. Cercenado (Hospital General Universitario ‘Gregorio Marañón’, Madrid, Spain); G. García-Pardo, J. Tapiol (Hospital Universitari ‘Joan XXIII’, Tarragona, Spain); J. P. Horcajada, M. Montero, M. Salvadó (Hospital Universitari del Mar, Barcelona, Spain); A. Arnáiz, C. Fernández (Hospital Universitario ‘Marqués de Valdecilla’, Santander, Spain); E. Calbo, M. Xercavins (Hospital Universitari Mútua de Terrassa, Terrassa, Spain); A. Granados, D. Fontanals (Corporació Sanitària Parc Taulí, Sabadell, Spain); V. Pintado, E. Loza (Hospital Universitario ‘Ramón y Cajal’, Madrid, Spain); J. Torre-Cisneros, R. Lara, F. Rodríguez-López, M. Rodríguez, C. Natera (Hospital Universitario ‘Reina Sofía’, Córdoba, Spain); J. R. Blanco, I. Olarte (Hospital Universitario ‘San Pedro’, Logroño, Spain); N. Benito, B. Mirelis (Hospital Universitari de la Santa Creu i Sant Pau, Barcelona, Spain); J. Murillas, E. Ruiz de Gopegui (Hospital Universitari Son Dureta, Palma de Mallorca, Spain); H. Espejo, M. A. Morera (Hospiyal de Terrassa, Terrassa, Spain); J. Rodríguez-Baño, E. López, A. Pascual (Hospital Universitario ‘Virgen Macarena’, Sevilla, Spain); C. Martín, J. A. Lepe, J. Molina (Hospital Universitario ‘Virgen del Rocío’, Sevilla, Spain); R. Sordé, B. Almirante, N. Larrosa (Hospital Universitari Vall d’Hebrón, Barcelona, Spain). [Background] It has been suggested that there is an increased risk of treatment failure in episodes of MRSA bloodstream infection (BSI) caused by strains with high vancomycin MICs. However, it is unknown if this phenomenon may also act as a risk factor for the development of infective endocarditis (IE). [Methods] We analysed 207 episodes of catheter-related (CR)-BSI recruited from June 2008 to December 2009 within a prospective study on MRSA BSI in 21 Spanish hospitals. Vancomycin susceptibility was centrally tested. The impact of high vancomycin MIC values (≥1.5 mg/L by Etest) on the subsequent development of IE was investigated by Cox regression. [Results] High vancomycin MIC values were observed in 46.9% of the isolates. Initial therapy consisted of vancomycin [99 episodes (44.7%)], daptomycin [25 (12.1%)], linezolid [18 (8.7%)] and other antistaphylococcal agents [16 (7.7%)]. Haematogenous complications occurred in 41 patients (19.8%), including 10 episodes complicated by IE. Early (48 h) and late (30 day) all-cause mortality were 3.4% and 25.1%, respectively. High vancomycin MIC isolates were more common among patients that developed IE compared with those free from this complication [90.9% (9/10) versus 44.7% (88/197); P = 0.007]. This association remained significant after adjusting for multiple confounders (including initial antibiotic therapy and catheter removal) in different models (minimum hazard ratio: 9.18; 95% CI: 1.16–72.78; P = 0.036). There were no differences in mortality according to vancomycin MIC values. [Conclusions] Decreased susceptibility to vancomycin acted as a predictor of the development of IE complicating MRSA CR-BSI. This study was co-funded by the Spanish Ministry of Economy and Competitiveness, Instituto de Salud Carlos III, Subdirección General de Redes y Centros de Investigación Cooperativa [co-financed by the European Development Regional Fund (ERDF) ‘A way to achieve Europe’] and by the Spanish Network for the Research in Infectious Diseases (REIPI RD12/0015). M. F. R. holds a clinical research contract ‘Juan Rodés’ (JR14/00036) from the Spanish Ministry of Economy and Competitiveness, Instituto de Salud Carlos III. |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9869233ee31221ba1715a98e9dfbc45 http://hdl.handle.net/10261/196752 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c9869233ee31221ba1715a98e9dfbc45 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |