Characteristics of finasteride users in comparison with nonusers: A Nordic nationwide study based on individual-level data from Denmark, Finland, and Sweden
| العنوان: | Characteristics of finasteride users in comparison with nonusers: A Nordic nationwide study based on individual-level data from Denmark, Finland, and Sweden |
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| المؤلفون: | Martha Emneus, Thora Majlund Kjærulff, Klaus Brasso, Eero Pukkala, Annette Kjær Ersbøll, Peter Iversen, Lau Caspar Thygesen, Anders Green, Kristian Bolin |
| المساهمون: | Yhteiskuntatieteiden tiedekunta - Faculty of Social Sciences, Tampere University |
| المصدر: | Kjærulff, T M, Ersbøll, A K, Pukkala, E, Bolin, K, Green, A, Emneus, M, Brasso, K, Iversen, P & Thygesen, L C 2020, ' Characteristics of finasteride users in comparison with nonusers : A Nordic nationwide study based on individual-level data from Denmark, Finland, and Sweden ', Pharmacoepidemiology and Drug Safety, vol. 29, no. 4, pp. 453-460 . https://doi.org/10.1002/pds.4947 Kjaerulff, T M, Ersbøll, A K, Pukkala, E, Bolin, K, Green, A, Emneus, M, Brasso, K, Iversen, P & Thygesen, L C 2020, ' Characteristics of finasteride users in comparison with nonusers : A Nordic nationwide study based on individual-level data from Denmark, Finland, and Sweden ', Pharmacoepidemiology and Drug Safety, vol. 29, no. 4, pp. 453-460 . https://doi.org/10.1002/pds.4947 |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Data Analysis, Male, medicine.medical_specialty, pharmacoepidemiology, Epidemiology, Kansanterveystiede, ympäristö ja työterveys - Public health care science, environmental and occupational health, Denmark, Population, Logistic regression, Testicular Diseases, 030226 pharmacology & pharmacy, Breast Neoplasms, Male, 03 medical and health sciences, chemistry.chemical_compound, 5-alpha Reductase Inhibitors, 0302 clinical medicine, Syöpätaudit - Cancers, medicine, Humans, Pharmacology (medical), Registries, 030212 general & internal medicine, education, Finland, Aged, Aged, 80 and over, Sweden, education.field_of_study, business.industry, Finasteride, registries, Confounding Factors, Epidemiologic, Odds ratio, Middle Aged, Pharmacoepidemiology, medicine.disease, Confidence interval, finasteride, chemistry, Case-Control Studies, Male breast cancer, surveys and questionnaires, surveys and questionnaire, business, Demography, Farmasia - Pharmacy |
| الوصف: | PURPOSE: Published epidemiological studies on the association between finasteride use and the risk of male breast cancer have been inconclusive due to methodological limitations including a few male breast cancer cases included. Determinants of male breast cancer have been studied, but it remains unexplored whether these are also related to finasteride use and thereby constitute potential confounders. This study aimed to assess whether there are differences between finasteride users and nonusers with regard to numerous potential confounders.METHODS: In total, 246 508 finasteride users (≥35 years) were identified in the prescription registries of Denmark (1995-2014), Finland (1997-2013), and Sweden (2005-2014). An equal number of nonusers were sampled. The directed acyclic graph (DAG) methodology was used to identify potential confounders for the association between finasteride and male breast cancer. A logistic regression model compared finasteride users and nonusers with regard to potential confounders that were measurable in registries and population surveys.RESULTS: Finasteride users had higher odds of testicular abnormalities (odds ratio [OR] 1.40; 95% confidence interval [CI] 1.36-1.44), obesity (1.31; 1.23-1.39), exogenous testosterone (1.61; 1.48-1.74), radiation exposure (1.22; 1.18-1.27), and diabetes (1.07; 1.04-1.10) and lower odds of occupational exposure in perfume industry or in high temperature environments (0.93; 0.87-0.99), living alone (0.89; 0.88-0.91), living in urban/suburban areas (0.97; 0.95-0.99), and physical inactivity (0.70; 0.50-0.99) compared to nonusers.CONCLUSIONS: Systematic differences between finasteride users and nonusers were found emphasizing the importance of confounder adjustment of associations between finasteride and male breast cancer. |
| وصف الملف: | fulltext; application/pdf |
| اللغة: | English |
| DOI: | 10.1002/pds.4947 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9698cbf35d71628c33f137070db28ec https://trepo.tuni.fi/handle/10024/122132 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c9698cbf35d71628c33f137070db28ec |
| قاعدة البيانات: | OpenAIRE |
| DOI: | 10.1002/pds.4947 |
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