Differential association of cerebral blood flow and anisocytosis in APOE ε4 carriers at midlife
| العنوان: | Differential association of cerebral blood flow and anisocytosis in APOE ε4 carriers at midlife |
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| المؤلفون: | Maria-Eleni Dounavi, Elijah Mak, Peter Swann, Audrey Low, Graciela Muniz-Terrera, Anna McKeever, Marianna Pope, Guy B Williams, Katie Wells, Brian Lawlor, Lorina Naci, Paresh Malhotra, Clare Mackay, Ivan Koychev, Karen Ritchie, Li Su, Craig W Ritchie, John T O’Brien |
| المصدر: | Dounavi, M-E, Mak, E, Swann, P, Low, A, Muniz-Terrera, G, McKeever, A, Pope, M, Williams, G B, Wells, K, Lawlor, B, Naci, L, Malhotra, P, Mackay, C, Koychev, I, Ritchie, K, Su, L, Ritchie, C W & O'Brien, J T 2023, ' Differential association of cerebral blood flow and anisocytosis in APOE ε4 carriers at midlife ', Journal of Cerebral Blood Flow and Metabolism, pp. 271678X231173587 . https://doi.org/10.1177/0271678X231173587 |
| بيانات النشر: | SAGE Publications, 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Neurology, Neurology (clinical), Cardiology and Cardiovascular Medicine |
| الوصف: | Cerebral hemodynamic alterations have been observed in apolipoprotein ε4 (APOE4) carriers at midlife, however the physiological underpinnings of this observation are poorly understood. Our goal was to investigate cerebral blood flow (CBF) and its spatial coefficient of variation (CoV) in relation to APOE4 and a measure of erythrocyte anisocytosis (red blood cell distribution width – RDW) in a middle-aged cohort. Data from 563 participants in the PREVENT-Dementia study scanned with 3 T MRI cross-sectionally were analysed. Voxel-wise and region-of-interest analyses within nine vascular regions were run to detect areas of altered perfusion. Within the vascular regions, interaction terms between APOE4 and RDW in predicting CBF were examined. Areas of hyperperfusion in APOE4 carriers were detected mainly in frontotemporal regions. The APOE4 allele differentially moderated the association between RDW and CBF, an association which was more prominent in the distal vascular territories (p – [0.01, 0.05]). The CoV was not different between the considered groups. We provide novel evidence that in midlife, RDW and CBF are differentially associated in APOE4 carriers and non-carriers. This association is consistent with a differential hemodynamic response to hematological alterations in APOE4 carriers. |
| وصف الملف: | application/pdf |
| تدمد: | 1559-7016 0271-678X |
| DOI: | 10.1177/0271678x231173587 |
| DOI: | 10.1177/0271678X231173587 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c93388be3d7484da0251e17303f97ff9 https://doi.org/10.1177/0271678x231173587 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c93388be3d7484da0251e17303f97ff9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15597016 0271678X |
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| DOI: | 10.1177/0271678x231173587 |