A Steady-State Kinetic Analysis of the Prolyl-4-Hydroxylase Mechanism
| العنوان: | A Steady-State Kinetic Analysis of the Prolyl-4-Hydroxylase Mechanism |
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| المؤلفون: | Stephen A. Kuby, Norman T. Soskel |
| المصدر: | Connective Tissue Research. 9:121-125 |
| بيانات النشر: | Informa UK Limited, 1981. |
| سنة النشر: | 1981 |
| مصطلحات موضوعية: | chemistry.chemical_classification, Chemistry, Kinetic analysis, Procollagen-Proline Dioxygenase, Succinic Acid, Substrate (chemistry), chemistry.chemical_element, Thermodynamics, Succinates, Peptide, Cell Biology, Carbon Dioxide, Velocity equation, Kinetic energy, Biochemistry, Oxygen, Kinetics, Rheumatology, Mechanism (philosophy), Orthopedics and Sports Medicine, Collagen, Steady state (chemistry), Molecular Biology, Mathematics |
| الوصف: | Published kinetic data by Kivirikko, et al. on the prolyl-4-hydroxylase reaction have been re-evaluated using the overall steady-state velocity equation in the forward and reverse directions for an ordered ter ter kinetic mechanism. Qualitatively, the published data for prolyl-4-hydroxylase appear to fit the predicted patterns for this kinetic mechanism. More kinetic data are needed to confirm these results and to quantitate the kinetic parameters but, tentatively, the order of substrate addition would appear to be alpha-ketoglutarate, oxygen, and peptide; and the order of product release would be hydroxylated peptide (or collagen), carbon dioxide, and succinate. |
| تدمد: | 1607-8438 0300-8207 |
| DOI: | 10.3109/03008208109160250 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c933021ef97df89c53eb677ac58a5ee5 https://doi.org/10.3109/03008208109160250 |
| رقم الانضمام: | edsair.doi.dedup.....c933021ef97df89c53eb677ac58a5ee5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16078438 03008207 |
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| DOI: | 10.3109/03008208109160250 |