Standardized Extract of Atractylodis Rhizoma Alba and Fructus Schisandrae Ameliorates Coughing and Increases Expectoration of Phlegm
| العنوان: | Standardized Extract of Atractylodis Rhizoma Alba and Fructus Schisandrae Ameliorates Coughing and Increases Expectoration of Phlegm |
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| المؤلفون: | Jong Lae Lim, Young-Won Chin, Sun-Young Kim, Sun-Woo Joo, Pisey Pel, Yun Young Lim, Jungmoo Huh, Shin Jung Park, Hee-Sung Chae |
| المصدر: | Molecules Molecules, Vol 25, Iss 3064, p 3064 (2020) Volume 25 Issue 13 |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Lipopolysaccharides, Pharmaceutical Science, Pharmacology, Analytical Chemistry, chemistry.chemical_compound, 0302 clinical medicine, Drug Discovery, Respiratory system, Cells, Cultured, Expectorants, Schisandra, 0303 health sciences, Respiratory tract infections, Phlegm, TRPV-1, Atractylodis Rhizoma Alba, Chemistry (miscellaneous), Mucociliary Clearance, Molecular Medicine, Bronchitis, medicine.symptom, Inflammation Mediators, phlegm, Mucociliary clearance, Guinea Pigs, Bronchi, Article, lcsh:QD241-441, 03 medical and health sciences, lcsh:Organic chemistry, medicine, Animals, Humans, Interleukin 8, CKD-497, Physical and Theoretical Chemistry, 030304 developmental biology, Inflammation, business.industry, Plant Extracts, Organic Chemistry, Mucin, Sputum, Fructus Schisandrae, interleukin-8, Atractylodes, medicine.disease, respiratory tract diseases, 030228 respiratory system, chemistry, Cough, Capsaicin, TNF-α, business |
| الوصف: | Cough and phlegm frequently occur in respiratory diseases like upper respiratory tract infections, acute bronchitis, and chronic obstructive pulmonary diseases. To relieve these symptoms and diseases, various ingredients are being used despite the debates on their clinical efficacy. We aimed to investigate the effects of the extract CKD-497, composed of Atractylodis Rhizoma Alba and Fructus Schisandrae, in relieving cough and facilitating expectoration of phlegm. CKD-497 was found to inhibit inflammatory mediators such as interleukin-8 (IL-8) and tumor necrosis factor &alpha (TNF-&alpha ) in lipopolysaccharide (LPS)-treated mouse macrophages and transient receptor potential cation channel 1 (TRPV-1)-overexpressed human bronchial epithelial cells stimulated by capsaicin. CKD-497 decreased the viscosity of the mucin solution. During in vivo experiments, CKD-497 reduced coughing numbers and increased expectoration of phlegm via mucociliary clearance enhancement. Collectively, these data suggest that CKD-497 possesses potential for cough and phlegm expectoration treatment. |
| وصف الملف: | application/pdf |
| تدمد: | 1420-3049 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8e14afc56b1c8f3828480c819b05c31 https://pubmed.ncbi.nlm.nih.gov/32635583 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c8e14afc56b1c8f3828480c819b05c31 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14203049 |
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