Utility of vertebral biopsy before vertebroplasty in patients with diagnosis of vertebral compression fracture
| العنوان: | Utility of vertebral biopsy before vertebroplasty in patients with diagnosis of vertebral compression fracture |
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| المؤلفون: | Federica Tavani, Mirko Trentadue, Carlo Sozzi, Lisa Nicolì, E. Piovan |
| المصدر: | La radiologia medica. 126:956-962 |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Osteoporosis, 030218 nuclear medicine & medical imaging, Hemangioma, 03 medical and health sciences, 0302 clinical medicine, Fractures, Compression, Biopsy, medicine, Humans, Radiology, Nuclear Medicine and imaging, Spondylitis, Multiple myeloma, Aged, Retrospective Studies, Neuroradiology, Aged, 80 and over, Vertebroplasty, Lumbar Vertebrae, medicine.diagnostic_test, business.industry, Vertebral compression fracture, Biopsy, Needle, Interventional radiology, General Medicine, Middle Aged, medicine.disease, 030220 oncology & carcinogenesis, Preoperative Period, Spinal Fractures, Female, Radiology, business |
| الوصف: | To demonstrate the utility of a biopsy performed just before vertebroplasty in patients with diagnosis of vertebral compression fracture (VCF) and no history of neoplastic or hematologic diseases. Osteoporosis is the most frequent cause of vertebral compression fracture, with trauma and pathologic vertebral weakening being other common causes. Since secondary fractures at imaging investigation can present as simple compression fractures, it is important to identify an underlying pathology. The aim of this paper is to evaluate the frequency of unexpected positive histology in vertebral samples withdrawn from patients undergoing a vertebroplasty to evaluate if a vertebral biopsy can routinely be used in case of VCF and when a secondary cause is not suspected. We retrospectively evaluated the results of 324 biopsies performed from February 2003 to March 2019 just before vertebroplasty in 1183 patients diagnosed with one or more vertebral compression fractures and with no history of neoplastic or hematological diseases and with no suspicious findings for secondary fractures at imaging. Biopsy was not diagnostic in 9/324 cases (2.8%); osteoporosis was the diagnosis in 295 cases (91%); in the remaining 20 cases (6.2%), histology was positive for an underlying pathology: 12/20 (60% of positive cases) multiple myeloma; 5/20 (25%) lymphoma/leukemia; 1/20 (5%) spondylitis; 1/20 (5%) metastasis; 1/20 (5%) hemangioma. A significantly higher incidence of positive biopsies was found in patients younger than 73 (p = 0.01) with 17 of 20 (85%) positive biopsies. No complications related to the bioptic maneuver were found, according to CIRSE guidelines on percutaneous needle biopsy. Vertebral biopsy is a safe procedure with no related complications. In our series, an unexpected diagnosis was found in 6% of cases with impact on patient’s clinical management. Positive unexpected histology was significantly higher in younger patients. In conclusion, we believe that a biopsy is useful and should be performed on all patients with vertebral compression fractures before a vertebroplasty. |
| تدمد: | 1826-6983 0033-8362 |
| DOI: | 10.1007/s11547-021-01353-9 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c87e576fdc77046c8cabe9639e410062 https://doi.org/10.1007/s11547-021-01353-9 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....c87e576fdc77046c8cabe9639e410062 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18266983 00338362 |
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| DOI: | 10.1007/s11547-021-01353-9 |