Extended surgical safety margins and ulceration are associated with an improved prognosis in pleomorphic dermal sarcomas
| العنوان: | Extended surgical safety margins and ulceration are associated with an improved prognosis in pleomorphic dermal sarcomas |
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| المؤلفون: | M. Emberger, Marion Wobser, Doris Helbig, Carmen Loquai, Oana-Diana Persa, Alexander Kreuter, Cornelia Mauch, A. Volz, S. Dengler, M. Baltaci, M. Doerler, Martin Laimer |
| المصدر: | Journal of the European Academy of Dermatology and Venereology. 33:1577-1580 |
| بيانات النشر: | Wiley, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, Oncology, medicine.medical_specialty, Skin Neoplasms, medicine.medical_treatment, Dermatology, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Statistical significance, Surgical safety, Humans, Medicine, Intermediate Grade, Ulcer, Aged, Aged, 80 and over, business.industry, Proportional hazards model, Hazard ratio, Margins of Excision, food and beverages, Sarcoma, Immunosuppression, Middle Aged, Prognosis, Confidence interval, 030104 developmental biology, Infectious Diseases, 030220 oncology & carcinogenesis, Cohort, Female, business |
| الوصف: | BACKGROUND Pleomorphic dermal sarcomas (PDS) are frequent UV-induced sarcomas of the skin of intermediate grade malignant potential. Despite the fact that PDS have a noteworthy potential to recur (up to 28%) as well as to metastasize (up to 20%), there are no specific clinical guidelines with respect to follow-up these patients. Moreover, little is known about clinical, histological or molecular prognostic factors in PDS. OBJECTIVE The aim of the present study was to identify risk factors to predict relapse in a large multicentre sample cohort of PDS which could aid to optimize personalized treatment recommendations regarding surgical safety margins and adjuvant radiotherapy. METHODS Patients with a diagnosis of PDS were selected from nine European institutions based on the histopathologic criteria described by Fletcher. Clinicopathologic and follow-up data were collected and statistically analysed calculating univariate hazard ratios with 95% confidence intervals by use of the Cox proportional-hazards model and a significance level of P |
| تدمد: | 1468-3083 0926-9959 |
| DOI: | 10.1111/jdv.15493 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8383794ef8c0cb4832f0e122a0fc02b https://doi.org/10.1111/jdv.15493 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....c8383794ef8c0cb4832f0e122a0fc02b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14683083 09269959 |
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| DOI: | 10.1111/jdv.15493 |