Different Expression of Mitochondrial and Endoplasmic Reticulum Stress Genes in Epicardial Adipose Tissue Depends on Coronary Atherosclerosis
| العنوان: | Different Expression of Mitochondrial and Endoplasmic Reticulum Stress Genes in Epicardial Adipose Tissue Depends on Coronary Atherosclerosis |
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| المؤلفون: | Milos Mraz, Jakub Mahrík, Ivana Laňková, Jaroslava Trnovska, Ivan Netuka, Peter Novodvorský, Zdeňka Lacinová, Martin Haluzik, Anna Cinkajzlová, Helena Kratochvilova, Daniel Hlavacek, Barbora Judita Kasperova, Peter Ivak, Zdeněk Matloch |
| المصدر: | International Journal of Molecular Sciences, Vol 22, Iss 4538, p 4538 (2021) International Journal of Molecular Sciences Volume 22 Issue 9 |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Adipose tissue, 030204 cardiovascular system & hematology, Endoplasmic Reticulum, Coronary artery disease, 0302 clinical medicine, Biology (General), Spectroscopy, General Medicine, Middle Aged, Mitochondria, Computer Science Applications, Chemistry, medicine.anatomical_structure, Mitochondrial respiratory chain, Adipose Tissue, diabetes mellitus, cardiovascular system, endoplasmic reticulum stress, Female, Pericardium, cardiac surgery, coronary artery disease, Artery, medicine.medical_specialty, epicardial fat, QH301-705.5, Subcutaneous Fat, Article, Catalysis, Inorganic Chemistry, 03 medical and health sciences, Internal medicine, mitochondrial dysfunction, medicine, Humans, RNA, Messenger, cardiovascular diseases, Physical and Theoretical Chemistry, Muscle, Skeletal, QD1-999, Molecular Biology, Coronary atherosclerosis, Aged, business.industry, Gene Expression Profiling, Myocardium, Endoplasmic reticulum, Organic Chemistry, Skeletal muscle, medicine.disease, 030104 developmental biology, Endocrinology, inflammation, gene expression, Unfolded protein response, Transcriptome, business |
| الوصف: | The aim of our study was to analyze mitochondrial and endoplasmic reticulum (ER) gene expression profiles in subcutaneous (SAT) and epicardial (EAT) adipose tissue, skeletal muscle, and myocardium in patients with and without CAD undergoing elective cardiac surgery. Thirty-eight patients, 27 with (CAD group) and 11 without CAD (noCAD group), undergoing coronary artery bypass grafting and/or valvular surgery were included in the study. EAT, SAT, intercostal skeletal muscle, and right atrium tissue and blood samples were collected at the start and end of surgery mRNA expression of selected mitochondrial and ER stress genes was assessed using qRT-PCR. The presence of CAD was associated with decreased mRNA expression of most of the investigated mitochondrial respiratory chain genes in EAT, while no such changes were seen in SAT or other tissues. In contrast, the expression of ER stress genes did not differ between the CAD and noCAD groups in almost any tissue. Cardiac surgery further augmented mitochondrial dysfunction in EAT. In our study, CAD was associated with decreased expression of mitochondrial, but not endoplasmic reticulum stress genes in EAT. These changes may contribute to the acceleration of coronary atherosclerosis. |
| وصف الملف: | application/pdf |
| تدمد: | 1422-0067 |
| DOI: | 10.3390/ijms22094538 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c79b8cda6817ac432d2649d8da0609a3 https://doi.org/10.3390/ijms22094538 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c79b8cda6817ac432d2649d8da0609a3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14220067 |
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| DOI: | 10.3390/ijms22094538 |