A mode-of-action ontology model for safety evaluation of chemicals: Outcome of a series of workshops on repeated dose toxicity
| العنوان: | A mode-of-action ontology model for safety evaluation of chemicals: Outcome of a series of workshops on repeated dose toxicity |
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| المؤلفون: | Bruno Hubesch, Barbara Birk, Andrea Richarz, Alan R. Boobis, Michael Schwarz, Paul Jennings, Dinant Kroese, Bas J. Blaauboer, Catherine Mahony, Gladys Ouedraogo, Mathieu Vinken, Martina Klaric, Mark T. D. Cronin, Bertrand Desprez, Paul L. Carmichael, Richard Curie, Bob van de Water, Jan van Benthem, Aldert H. Piersma, George P. Daston |
| المساهمون: | Molecular and Computational Toxicology, AIMMS, Liver Connexin and Pannexin Research Group, Pharmaceutical and Pharmacological Sciences, Connexin Signalling Research Group, Experimental in vitro toxicology and dermato-cosmetology |
| المصدر: | Toxicology In Vitro, 59, 44-50 59, 44-50 Toxicology in Vitro, 59, 44-50. Elsevier Limited Desprez, B, Birk, B, Blaauboer, B, Boobis, A, Carmichael, P, Cronin, M T D, Curie, R, Daston, G, Hubesch, B, Jennings, P, Klaric, M, Kroese, D, Mahony, C, Ouédraogo, G, Piersma, A, Richarz, A N, Schwarz, M, van Benthem, J, van de Water, B & Vinken, M 2019, ' A mode-of-action ontology model for safety evaluation of chemicals : Outcome of a series of workshops on repeated dose toxicity ', Toxicology in Vitro, vol. 59, pp. 44-50 . https://doi.org/10.1016/j.tiv.2019.04.005 |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Mode-of-action, 0301 basic medicine, Computer science, Cytotoxicity, Cosmetics, Ontology (information science), Toxicology, Outcome (game theory), Workflow, 0302 clinical medicine, Chemical structure, Adverse Outcome Pathway, Biotransformation, Toxicity data, Ontology, General Medicine, Organ distribution, Physical chemistry, Risk analysis (engineering), Mode of action, 030220 oncology & carcinogenesis, Toxicity, Safety, Human, RM, Chemical parameters, Animal Testing Alternatives, Risk Assessment, Hazardous Substances, Exposure, Adverse outcome, 03 medical and health sciences, Adverse outcome pathway, Toxicity Tests, Cosmetic, Animals, Humans, Ontology model, Set (psychology), Repeated dose toxicity, Nonhuman, Note, Kinetics, Metabolism, 030104 developmental biology, Action (philosophy), Biological Ontologies, Consumer Product Safety, Toxicity testing |
| الوصف: | Repeated dose toxicity evaluation aims at assessing the occurrence of adverse effects following chronic or repeated exposure to chemicals. Non-animal approaches have gained importance in the last decades because of ethical considerations as well as due to scientific reasons calling for more human-based strategies. A critical aspect of this challenge is linked to the capacity to cover a comprehensive set of interdependent mechanisms of action, link them to adverse effects and interpret their probability to be triggered in the light of the exposure at the (sub)cellular level. Inherent to its structured nature, an ontology addressing repeated dose toxicity could be a scientific and transparent way to achieve this goal. Additionally, repeated dose toxicity evaluation through the use of a harmonized ontology should be performed in a reproducible and consistent manner, while mimicking as accurately as possible human physiology and adaptivity. In this paper, the outcome of a series of workshops organized by Cosmetics Europe on this topic is reported. As such, this manuscript shows how experts set critical elements and ways of establishing a mode-of-action ontology model as a support to risk assessors aiming to perform animal-free safety evaluation of chemicals based on repeated dose toxicity data. |
| وصف الملف: | application/pdf |
| تدمد: | 1879-3177 0887-2333 |
| DOI: | 10.1016/j.tiv.2019.04.005 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7933a00d77165536cc9ac0282cd7c74 https://pubmed.ncbi.nlm.nih.gov/30954655 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c7933a00d77165536cc9ac0282cd7c74 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18793177 08872333 |
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| DOI: | 10.1016/j.tiv.2019.04.005 |