Biomechanical Modeling to Inform Pulmonary Valve Replacement in Tetralogy of Fallot Patients after Complete Repair
| العنوان: | Biomechanical Modeling to Inform Pulmonary Valve Replacement in Tetralogy of Fallot Patients after Complete Repair |
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| المؤلفون: | Gerald F. Greil, Radomir Chabiniok, Keren Hasbani, Dominique Chapelle, Camille L. Hancock Friesen, Maria Gusseva, Animesh Tandon, Cécile Patte, Philippe Moireau, Tarique Hussain, Martin Genet |
| المساهمون: | Mathematical and Mechanical Modeling with Data Interaction in Simulations for Medicine (M3DISIM), Laboratoire de mécanique des solides (LMS), École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), University of Texas Southwestern Medical Center [Dallas], University of Texas at Austin [Austin], Czech Technical University in Prague (CTU), King‘s College London, Guy's and St Thomas' Hospital [London], École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris |
| المصدر: | Canadian Journal of Cardiology Canadian Journal of Cardiology, 2021, 37, pp.1798-1807. ⟨10.1016/j.cjca.2021.06.018⟩ Canadian Journal of Cardiology, Elsevier, 2021, 37, pp.1798-1807. ⟨10.1016/j.cjca.2021.06.018⟩ Can J Cardiol |
| بيانات النشر: | HAL CCSD, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Male, Reoperation, medicine.medical_specialty, Percutaneous, Heart Ventricles, 0206 medical engineering, Magnetic Resonance Imaging, Cine, 02 engineering and technology, 030204 cardiovascular system & hematology, Models, Biological, Article, Contractility, 03 medical and health sciences, 0302 clinical medicine, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Cardiovascular modeling, Pulmonary Valve Replacement, Internal medicine, medicine.artery, Humans, Medicine, Abnormalities, Multiple, Cardiac Surgical Procedures, Retrospective Studies, Tetralogy of Fallot, Heart Valve Prosthesis Implantation, Cardiovascular magnetic resonance imaging, Pulmonary Valve, medicine.diagnostic_test, business.industry, Hemodynamics, Magnetic resonance imaging, Retrospective cohort study, Translational research, medicine.disease, 020601 biomedical engineering, Personalized medicine, Pulmonary Valve Insufficiency, Pulmonary artery, Cardiology, Female, Biomechanical model, [SDV.IB]Life Sciences [q-bio]/Bioengineering, Myocardial contractility, Cardiology and Cardiovascular Medicine, business, Follow-Up Studies |
| الوصف: | BACKGROUND: A biomechanical model of the heart can be used to incorporate multiple data sources (electrocardiography, imaging, invasive hemodynamics). The purpose of this study was to use this approach in a cohort of patients with tetralogy of Fallot after complete repair (rTOF) to assess comparative influences of residual right ventricular outflow tract obstruction (RVOTO) and pulmonary regurgitation on ventricular health. METHODS: Twenty patients with rTOF who underwent percutaneous pulmonary valve replacement (PVR) and cardiovascular magnetic resonance imaging were included in this retrospective study. RESULTS: RV contractility before PVR (mean 66 ± kPa, mean ± standard deviation) was increased in patients with rTOF compared with normal RV (38–48 kPa) (P < 0.05). The contractility decreased significantly in all patients after PVR (P < 0.05). Patients with predominantly RVOTO demonstrated greater reduction in contractility (median decrease 35%) after PVR than those with predominant pulmonary regurgitation (median decrease 11%). The model simulated post-PVR decreased EDV for the majority and suggested an increase of Q(eff)—both in line with published data. CONCLUSIONS: This study used a biomechanical model to synthesize multiple clinical inputs and give an insight into RV health. Individualized modeling allows us to predict the RV response to PVR. Initial data suggest that residual RVOTO imposes greater ventricular work than isolated pulmonary regurgitation. Biomechanical models specific to individual patient and physiology (before and after PVR) were created and used to estimate the RV myocardial contractility. The ability of models to capture post-PVR changes of right ventricular (RV) end-diastolic volume (EDV) and effective flow in the pulmonary artery (Qeff) was also compared with expected values. |
| اللغة: | English |
| تدمد: | 0828-282X 1916-7075 |
| DOI: | 10.1016/j.cjca.2021.06.018⟩ |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c708fdef9c7c70f7176d72caf44645d0 https://inria.hal.science/hal-03313844 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c708fdef9c7c70f7176d72caf44645d0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 0828282X 19167075 |
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| DOI: | 10.1016/j.cjca.2021.06.018⟩ |