The transcription factor ATF7 mediates lipopolysaccharide-induced epigenetic changes in macrophages involved in innate immunological memory
| العنوان: | The transcription factor ATF7 mediates lipopolysaccharide-induced epigenetic changes in macrophages involved in innate immunological memory |
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| المؤلفون: | Katsuhiko Shirahige, Keisuke Yoshida, Takuji Yamada, Kentaro Inoue, Bruno Chatton, Ken-ichi Ishibashi, Yujuan Zhu, Toshio Maekawa, Naohito Ohno, Takeru Uchiyama, Shunsuke Ishii, Claire Renard-Guillet, Mariko Okada-Hatakeyama |
| المصدر: | Nature Immunology. 16:1034-1043 |
| بيانات النشر: | Springer Science and Business Media LLC, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Lipopolysaccharides, Innate immune system, biology, Lipopolysaccharide, Reverse Transcriptase Polymerase Chain Reaction, Kinase, Macrophages, Immunology, Innate lymphoid cell, Activating Transcription Factors, Epigenesis, Genetic, Chromatin, Mice, chemistry.chemical_compound, Histone, chemistry, biology.protein, Animals, Immunology and Allergy, Epigenetics, Immunologic Memory, Transcription factor |
| الوصف: | Immunological memory is thought to be mediated exclusively by lymphocytes. However, enhanced innate immune responses caused by a previous infection increase protection against reinfection, which suggests the presence of innate immunological memory. Here we identified an important role for the stress-response transcription factor ATF7 in innate immunological memory. ATF7 suppressed a group of genes encoding factors involved in innate immunity in macrophages by recruiting the histone H3K9 dimethyltransferase G9a. Treatment with lipopolysaccharide, which mimics bacterial infection, induced phosphorylation of ATF7 via the kinase p38, which led to the release of ATF7 from chromatin and a decrease in repressive histone H3K9me2 marks. A partially disrupted chromatin structure and increased basal expression of target genes were maintained for long periods, which enhanced resistance to pathogens. ATF7 might therefore be important in controlling memory in cells of the innate immune system. |
| تدمد: | 1529-2916 1529-2908 |
| DOI: | 10.1038/ni.3257 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c704b93a83df387f70f030cea27ec064 https://doi.org/10.1038/ni.3257 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....c704b93a83df387f70f030cea27ec064 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15292916 15292908 |
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| DOI: | 10.1038/ni.3257 |