Risk factors for acute respiratory distress syndrome development in patients with type A influenza (H1N1)
| العنوان: | Risk factors for acute respiratory distress syndrome development in patients with type A influenza (H1N1) |
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| المؤلفون: | Zorana Djordjevic, Radojica Stolic, Predrag Canovic, Zeljko Mijailovic, Zorica Lazic, Zoran Todorovic, Olgica Gajovic, Zoran Bukumiric |
| المصدر: | Srpski Arhiv za Celokupno Lekarstvo, Vol 140, Iss 7-8, Pp 441-447 (2012) |
| بيانات النشر: | National Library of Serbia, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, ARDS, lcsh:Medicine, Disease, acute respiratory distress syndrome(ARDS), Logistic regression, Influenza A Virus, H1N1 Subtype, Internal medicine, Diabetes mellitus, Influenza, Human, medicine, Flu season, Humans, risk factors, Intensive care medicine, influenza A (H1N1), Respiratory Distress Syndrome, business.industry, Medical record, lcsh:R, General Medicine, medicine.disease, Complication, business, Case series |
| الوصف: | Introduction. Acute respiratory distress syndrome (ARDS) is a significant complication in patients with type A influenza (H1N1) due to the severity of the disease and adverse outcome. Objective. The aim of the study was to identify risk factors for the development of ARDS in patients with type A influenza (H1N1) and outcome of ARDS. Methods. The research was conducted as a case series study, and included patients admitted at the Clinical Center in Kragujevac during the 2009 and 2010 flu season. Data for the study were obtained from patients’ medical records, inclusion criteria having been determined in accordance with recommendations of the Expert Methodological Guide for Controlling Spread of Pandemic Influenza in the Republic of Serbia. Primary data analysis was performed using descriptive statistics and a statistical method for testing hypotheses. Dependence analysis was performed using simple logistic regression. The statistical hypotheses were tested at the 0.05 level of significance. Results. The case group consisted of 14 patients who developed ARDS, while the control group was composed of 34 patients with influenza but without ARDS (group alignment performed by age). Simple logistic regression analysis identified the following risk factors for the development of ARDS: diabetes mellitus type 1 or 2 (p=0.028), high levels of C-reactive protein (p=0.004), aspartate-aminotransferase (p=0.006), urea (p=0.028), creatine kinase (p=0.001), lactate-dehydrogenase (p=0.005) and longer time elapsed from disease symptoms onset to the administration of specific antiviral therapy administration (p=0.021). Conclusion. The research showed that diabetes, late initiation of antiviral therapy and some laboratory tests are risk factors for ARDS development in patients with type A influenza (H1N1). |
| تدمد: | 2406-0895 0370-8179 |
| DOI: | 10.2298/sarh1208441d |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7019de6f652c4d9106398e97eff3d1b https://doi.org/10.2298/sarh1208441d |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c7019de6f652c4d9106398e97eff3d1b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 24060895 03708179 |
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| DOI: | 10.2298/sarh1208441d |