Effects of PEEP on the relationship between tidal volume and total impedance change measured via electrical impedance tomography (EIT)

التفاصيل البيبلوغرافية
العنوان: Effects of PEEP on the relationship between tidal volume and total impedance change measured via electrical impedance tomography (EIT)
المؤلفون: Andreas D. Waldmann, Anthea L. Raisis, Martina Mosing, O. Brabant, Andy Adler, Benedetta Crivellari, Ulrike Auer, Lisa Smart, Michael Laurence, Giselle Hosgood
المصدر: Journal of Clinical Monitoring and Computing
بيانات النشر: Springer Netherlands, 2021.
سنة النشر: 2021
مصطلحات موضوعية: Spirometry, Male, medicine.medical_specialty, Dead space, Health Informatics, Pulmonary monitoring, Respiratory physiology, Peak inspiratory pressure, Critical Care and Intensive Care Medicine, law.invention, Anaesthesia, Positive-Pressure Respiration, 03 medical and health sciences, 0302 clinical medicine, 030202 anesthesiology, law, Internal medicine, Linear regression, medicine, Electric Impedance, Tidal Volume, Animals, Humans, Electrical impedance tomography, Tomography, Tidal volume, Original Research, medicine.diagnostic_test, business.industry, 030208 emergency & critical care medicine, respiratory system, respiratory tract diseases, Anesthesiology and Pain Medicine, Cardiology, Cattle, Volumetric capnography, business, Tomography, X-Ray Computed, Spirometer
الوصف: Electrical impedance tomography (EIT) is used in lung physiology monitoring. There is evidence that EIT is linearly associated with global tidal volume (VT) in clinically healthy patients where no positive end-expiratory pressure (PEEP) is applied. This linearity has not been challenged by altering lung conditions. The aim of this study was to determine the effect of PEEP on VT estimation, using EIT technology and spirometry, and observe the stability of the relationship under changing lung conditions. Twelve male castrated cattle (Steer), mean age 7.8 months (SD ± 1.7) were premedicated with xylazine followed by anaesthesia induction with ketamine and maintenance with halothane in oxygen via an endotracheal tube. An EIT belt was applied around the thorax at the level of the fifth intercostal space. Volume controlled ventilation was used. PEEP was increased in a stepwise manner from 0 to 5, 10 and 15 cmH2O. At each PEEP, the VT was increased stepwise from 5 to 10 and 15 mL kg−1. After a minute of stabilisation, total impedance change (VTEIT), using EIT and VT measured by a spirometer connected to a flow-partitioning device (VTSpiro) was recorded for the following minute before changing ventilator settings. Data was analysed using linear regression and multi variable analysis. There was a linear relationship between VTEIT and VTSpiro at all levels of PEEP with an R2 of 0.71, 0.68, 0.63 and 0.63 at 0, 5, 10 and 15 cmH2O, respectively. The variance in VTEIT was best described by peak inspiratory pressure (PIP) and PEEP (adjusted R2 0.82) while variance in VTSpiro was best described by PIP and airway deadspace (adjusted R2 0.76). The relationship between VTEIT and VTSpiro remains linear with changes in tidal volume, and stable across altered lung conditions. This may have application for monitoring and assessment in vivo.
اللغة: English
تدمد: 1573-2614
1387-1307
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c66d4b42c3894107d5b0d214c639d8c1
http://europepmc.org/articles/PMC7829490
Rights: OPEN
رقم الانضمام: edsair.doi.dedup.....c66d4b42c3894107d5b0d214c639d8c1
قاعدة البيانات: OpenAIRE