Quality assurance for the EORTC 22071-26071 study: Dummy run prospective analysis
| العنوان: | Quality assurance for the EORTC 22071-26071 study: Dummy run prospective analysis |
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| المؤلفون: | Wilfried Budach, M. Tomsej, Johannes A. Langendijk, Akos Gulyban, Christopher Scrase, Damien C. Weber, Alysa Fairchild, D. Schuring, Sandra Nuyts, Sunita Ghosh |
| المساهمون: | Damage and Repair in Cancer Development and Cancer Treatment (DARE), Guided Treatment in Optimal Selected Cancer Patients (GUTS) |
| المصدر: | Radiation oncology, 9:248. BMC Radiation Oncology (London, England) |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Organs at Risk, EORTC ROG, Dummy run, medicine.medical_specialty, Quality Assurance, Health Care, medicine.medical_treatment, Head and neck, Prospective analysis, Antineoplastic Combined Chemotherapy Protocols, Humans, Medicine, Panitumumab, Radiology, Nuclear Medicine and imaging, Medical physics, Prospective Studies, IMRT, Radiation treatment planning, Prospective cohort study, Squamous Cell Carcinoma of Head and Neck, business.industry, Radiotherapy Planning, Computer-Assisted, Research, Head and neck cancer, Antibodies, Monoclonal, Radiotherapy Dosage, Chemoradiotherapy, medicine.disease, Radiation therapy, Oncology, Head and Neck Neoplasms, Radiology Nuclear Medicine and imaging, Practice Guidelines as Topic, Carcinoma, Squamous Cell, Guideline Adherence, Radiotherapy, Intensity-Modulated, Radiology, business, Quality assurance, medicine.drug |
| الوصف: | Purpose The phase III 22071–26071 trial was designed to evaluate the addition of panitumumab to adjuvant chemotherapy plus intensity modulated radiotherapy (IMRT) in locally advanced resected squamous cell head and neck cancer. We report the results of the dummy run (DR) performed to detect deviations from protocol guidelines. Methods and Materials DR datasets consisting of target volumes, organs at risk (OAR) and treatment plans were digitally uploaded, then compared with reference contours and protocol guidelines by six central reviewers. Summary statistics and analyses of potential correlations between delineations and plan characteristics were performed. Results Of 23 datasets, 20 (87.0%) GTVs were evaluated as acceptable/borderline, along with 13 (56.5%) CTVs and 10 (43.5%) PTVs. All PTV dose requirements were met by 73.9% of cases. Dose constraints were met for 65.2-100% of mandatory OARs. Statistically significant correlations were observed between the subjective acceptability of contours and the ability to meet dose constraints for all OARs (p ≤ 0.01) except for the parotids and spinal cord. Ipsilateral parotid doses correlated significantly with CTV and PTV volumes (p ≤ 0.05). Conclusions The observed wide variations in treatment planning, despite strict guidelines, confirms the complexity of development and quality assurance of IMRT-based multicentre studies for head and neck cancer. Electronic supplementary material The online version of this article (doi:10.1186/s13014-014-0248-9) contains supplementary material, which is available to authorized users. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1748-717X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c65f1e9876457e661dd20fde359b1784 https://research.rug.nl/en/publications/a3a0f8a7-2255-4149-a4a6-b6e5272802f9 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c65f1e9876457e661dd20fde359b1784 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1748717X |
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