Changes in Vascular Distensibility during Angiotensin-Converting Enzyme Inhibition Involve Bradykinin Type 2 Receptors
| العنوان: | Changes in Vascular Distensibility during Angiotensin-Converting Enzyme Inhibition Involve Bradykinin Type 2 Receptors |
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| المؤلفون: | Jos F.M. Smits, Wendy M. Aartsen, P.M.H. Schiffers, Mat J.A.P. Daemen, Rob Hilgers, J.G.R. De Mey |
| المساهمون: | Other departments |
| المصدر: | Journal of vascular research, 41(1), 18-27. S. Karger AG |
| بيانات النشر: | S. Karger AG, 2004. |
| سنة النشر: | 2004 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Receptor, Bradykinin B2, Physiology, Adrenergic beta-Antagonists, Bradykinin, Blood Pressure, Peptidyl-Dipeptidase A, Mice, chemistry.chemical_compound, medicine.artery, Internal medicine, Bradykinin B2 Receptor Antagonists, medicine, Animals, Bradykinin receptor, Mesenteric arteries, Aorta, biology, Chemistry, Captopril, Angiotensin-converting enzyme, Arteries, medicine.disease, Mice, Mutant Strains, Mesenteric Arteries, Mice, Inbred C57BL, Carotid Arteries, medicine.anatomical_structure, Endocrinology, Blood pressure, Arterial stiffness, biology.protein, Female, Cardiology and Cardiovascular Medicine, medicine.drug |
| الوصف: | Changes in arterial stiffness and structure occur during cardiovascular diseases and can be modified by angiotensin-converting enzyme (ACE) inhibitors. In the present study we investigated the role of membrane-bound ACE (t-ACE) in the regulation of arterial structure and mechanics. Large and small arteries of t-ACE–/– mice were isolated to determine the passive pressure-diameter relationship. We observed that t-ACE–/– mice exhibit a reduced arterial distensibility compared to t-ACE+/+ mice. This reduced arterial distensibility was also observed after 9 weeks of captopril treatment (80 mg/kg/ day). We hypothesized that bradykinin type 2 receptor (BK2) stimulation might be involved in the regulation of arterial stiffness. t-ACE–/– and t-ACE+/+ mice were treated with Hoe 140 (1 mg/kg/day) for 14 days. After Hoe 140 treatment, both the structural and mechanical changes observed in the t-ACE–/– carotid artery were abolished. Although Hoe 140 administration increased blood pressure in both groups by approximately 10 mm Hg, the pressure difference between the two groups did not change. Thus, t-ACE is involved in the regulation of arterial distensibility. The changes observed in t-ACE–/– mice are not caused by an altered fetal development. Moreover, it is likely that the regulation of arterial distensibility by ACE involves stimulation of the BK2 receptor. |
| تدمد: | 1423-0135 1018-1172 |
| DOI: | 10.1159/000076125 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c64907d422cd5752f3a60b081a610d7f https://doi.org/10.1159/000076125 |
| Rights: | RESTRICTED |
| رقم الانضمام: | edsair.doi.dedup.....c64907d422cd5752f3a60b081a610d7f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14230135 10181172 |
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| DOI: | 10.1159/000076125 |